An Exploration of Traditional Chinese Medicinal Plants with Anti-Inflammatory Activities
Joint Authors
Fan, Chao
Jin, Hui-zi
Wu, Lehao
Zhang, Yu
Ye, Richard D.
Zhang, Yan
Zhang, Weidong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In a continuing effort to discover more anti-inflammatory medicinal plants in China, the anti-inflammatory activities of 101 extracts from different parts of 84 traditional medicinal plants were evaluated by a panel of in vitro and in vivo assays.
Nuclear factor-kappa B (NF-κB) inhibitory effects were determined by luciferase assay in stably transfected Hela cells.
Cytotoxic activities were assessed using the MTT assay.
Inhibitory effects on LPS-induced nitric oxide production and proinflammatory mediators were assessed by Griess reaction and Real-Time PCR analysis, respectively.
In vivo anti-inflammatory activities were examined by xylene-induced mice ear edema model.
In total, 22 extracts showed promising NF-κB inhibitory effects whereas 9 of them did not affect the cell viability.
The 9 hit extracts were active in at least one of the subsequently performed in vitro pharmacological test systems.
The extract from Hemerocallis minor (root) was selected to perform the in vivo study because it demonstrated significant suppressive effects in all the in vitro assays.
Results showed that the extract of Hemerocallis minor (Root) was able to alleviate ear edema effectively in xylene-induced mice ear edema mode.
Collectively, our study provides evidence for the potential anti-inflammatory effects of the medicinal plants traditionally used in China.
Further phytochemical and pharmacological studies remain to be clarified.
American Psychological Association (APA)
Fan, Chao& Jin, Hui-zi& Wu, Lehao& Zhang, Yu& Ye, Richard D.& Zhang, Weidong…[et al.]. 2017. An Exploration of Traditional Chinese Medicinal Plants with Anti-Inflammatory Activities. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152949
Modern Language Association (MLA)
Fan, Chao…[et al.]. An Exploration of Traditional Chinese Medicinal Plants with Anti-Inflammatory Activities. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1152949
American Medical Association (AMA)
Fan, Chao& Jin, Hui-zi& Wu, Lehao& Zhang, Yu& Ye, Richard D.& Zhang, Weidong…[et al.]. An Exploration of Traditional Chinese Medicinal Plants with Anti-Inflammatory Activities. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152949
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152949