Study on the Clinical Safe and Effective Methods of Arsenic-Containing Compound-Qinghuang Powder in the Treatment of Myelodysplastic Syndrome
Joint Authors
Xiaomei, Hu
Zhu, Qianzhe
Deng, Zhongyang
Zhu, Shirong
Zhao, Pan
Wang, Mingjing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To establish the clinical safe and effective methods of arsenic-containing compound-Qinghuang Powder (compound-QHP) in the treatment of myelodysplastic syndrome (MDS).
Methods.
200 patients with MDS were treated with compound-QHP (daily dose of 0.1 g realgar).
The blood arsenic concentrations (BACs) were detected by atomic fluorescence spectrophotometry (HF-AFS).
After treatment for 1 month, the patients were randomly divided into group A and group B when the BACs were less than 20 μg/L.
Daily dose of realgar was maintained in group A and it was increased to that when the BACs were more than 20 μg/L in group B.
The BAC and clinical efficacy and safety in two groups were compared at the end of the treatment with compound-QHP.
Results.
The average BAC of group B was significantly higher than that of group A (P<0.01).
The rates of hematology improvement and reduced transfusion were significantly higher in group B than in group A (P<0.05).
The HGB, ANC, and PLT significantly increased in group B after treatment (P>0.05).
Conclusions.
Monitoring the BAC and adjusting the daily dose of realgar to increase the effective BAC and then improving efficacy without increasing the clinical toxicity are the clinical safe and effective methods in the treatment of MDS.
American Psychological Association (APA)
Zhu, Qianzhe& Deng, Zhongyang& Zhu, Shirong& Zhao, Pan& Wang, Mingjing& Xiaomei, Hu. 2017. Study on the Clinical Safe and Effective Methods of Arsenic-Containing Compound-Qinghuang Powder in the Treatment of Myelodysplastic Syndrome. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1153208
Modern Language Association (MLA)
Zhu, Qianzhe…[et al.]. Study on the Clinical Safe and Effective Methods of Arsenic-Containing Compound-Qinghuang Powder in the Treatment of Myelodysplastic Syndrome. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1153208
American Medical Association (AMA)
Zhu, Qianzhe& Deng, Zhongyang& Zhu, Shirong& Zhao, Pan& Wang, Mingjing& Xiaomei, Hu. Study on the Clinical Safe and Effective Methods of Arsenic-Containing Compound-Qinghuang Powder in the Treatment of Myelodysplastic Syndrome. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1153208
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153208