Effects of the Aqueous Extract from Tabebuia roseoalba and Phenolic Acids on Hyperuricemia and Inflammation
Joint Authors
Ferraz-Filha, Zilma Schimith
Ferrari, Fernanda Cristina
Araújo, Marcela Carolina de Paula Michel
Bernardes, Ana Catharina Fernandes P. F.
Saúde-Guimarães, Dênia Antunes
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Tabebuia species (Bignoniaceae) have long been used in folk medicine as anti-inflammatory, antirheumatic, antimicrobial, and antitumor.
The aim of this study was to investigate if aqueous extract from the leaves (AEL) of Tabebuia roseoalba (Ridl.) Sandwith, Bignoniaceae, and its constituents could be useful to decrease serum uric acid levels and restrain the gout inflammatory process.
HPLC analysis identified caffeic acid and chlorogenic acid in AEL.
Antihyperuricemic effects and inhibition of liver XOD (xanthine oxidoreductase) by AEL and identified compounds were evaluated in hyperuricemic mice.
Anti-inflammatory activity was evaluated on MSU (monosodium urate) crystal-induced paw edema.
In addition, AEL antioxidant activity in vitro was evaluated.
AEL, caffeic, and chlorogenic acids were able to reduce serum uric acid levels in hyperuricemic mice probably through inhibition of liver xanthine oxidase activity and significantly decreased the paw edema induced by MSU crystals.
AEL showed significant antioxidant activity in all evaluated assays.
The results show that the AEL of Tabebuia roseoalba can be a promising agent for treatment for gout and inflammatory diseases.
We suggest that caffeic and chlorogenic acids may be responsible for the activities demonstrated by the species.
American Psychological Association (APA)
Ferraz-Filha, Zilma Schimith& Ferrari, Fernanda Cristina& Araújo, Marcela Carolina de Paula Michel& Bernardes, Ana Catharina Fernandes P. F.& Saúde-Guimarães, Dênia Antunes. 2017. Effects of the Aqueous Extract from Tabebuia roseoalba and Phenolic Acids on Hyperuricemia and Inflammation. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153316
Modern Language Association (MLA)
Ferraz-Filha, Zilma Schimith…[et al.]. Effects of the Aqueous Extract from Tabebuia roseoalba and Phenolic Acids on Hyperuricemia and Inflammation. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1153316
American Medical Association (AMA)
Ferraz-Filha, Zilma Schimith& Ferrari, Fernanda Cristina& Araújo, Marcela Carolina de Paula Michel& Bernardes, Ana Catharina Fernandes P. F.& Saúde-Guimarães, Dênia Antunes. Effects of the Aqueous Extract from Tabebuia roseoalba and Phenolic Acids on Hyperuricemia and Inflammation. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153316
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153316