Anti-Inflammatory Activity of Babassu Oil and Development of a Microemulsion System for Topical Delivery
Joint Authors
Silva, Márcia Vanusa da
Mattos, Alessandra B.
Santos, Simone Maria dos
Reis, Mysrayn Y. F. A.
Silva, Danielle R.
Navarro, Daniela M. A. Ferraz
Santos, Geanne K. N.
Hallwass, Fernando
Bianchi, Otávio
Melo, Janaína V.
Machado, Giovanna
Saraiva, Karina L. A.
Correia, Maria Tereza dos Santos
da Silva, Alexandre Gomes
Ximenes, Rafael Matos
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-21
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Babassu oil extraction is the main income source in nut breakers communities in northeast of Brazil.
Among these communities, babassu oil is used for cooking but also medically to treat skin wounds and inflammation, and vulvovaginitis.
This study aimed to evaluate the anti-inflammatory activity of babassu oil and develop a microemulsion system with babassu oil for topical delivery.
Topical anti-inflammatory activity was evaluated in mice ear edema using PMA, arachidonic acid, ethyl phenylpropiolate, phenol, and capsaicin as phlogistic agents.
A microemulsion system was successfully developed using a Span® 80/Kolliphor® EL ratio of 6 : 4 as the surfactant system (S), propylene glycol and water (3 : 1) as the aqueous phase (A), and babassu oil as the oil phase (O), and analyzed through conductivity, SAXS, DSC, TEM, and rheological assays.
Babassu oil and lauric acid showed anti-inflammatory activity in mice ear edema, through inhibition of eicosanoid pathway and bioactive amines.
The developed formulation (39% A, 12.2% O, and 48.8% S) was classified as a bicontinuous to o/w transition microemulsion that showed a Newtonian profile.
The topical anti-inflammatory activity of microemulsified babassu oil was markedly increased.
A new delivery system of babassu microemulsion droplet clusters was designed to enhance the therapeutic efficacy of vegetable oil.
American Psychological Association (APA)
Reis, Mysrayn Y. F. A.& Santos, Simone Maria dos& Silva, Danielle R.& Silva, Márcia Vanusa da& Correia, Maria Tereza dos Santos& Navarro, Daniela M. A. Ferraz…[et al.]. 2017. Anti-Inflammatory Activity of Babassu Oil and Development of a Microemulsion System for Topical Delivery. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1153548
Modern Language Association (MLA)
Reis, Mysrayn Y. F. A.…[et al.]. Anti-Inflammatory Activity of Babassu Oil and Development of a Microemulsion System for Topical Delivery. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1153548
American Medical Association (AMA)
Reis, Mysrayn Y. F. A.& Santos, Simone Maria dos& Silva, Danielle R.& Silva, Márcia Vanusa da& Correia, Maria Tereza dos Santos& Navarro, Daniela M. A. Ferraz…[et al.]. Anti-Inflammatory Activity of Babassu Oil and Development of a Microemulsion System for Topical Delivery. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1153548
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153548