1H NMR-Based Metabonomic Study of Functional Dyspepsia in Stressed Rats Treated with Chinese Medicine Weikangning
Joint Authors
Wei, Wei
Chen, Jiande DZ
Li, Zhongfeng
Zhu, Jia-Jie
Su, Xiao-Lan
Li, Yi-Jie
Wei, Ru-Han
Yang, Jian-Qin
Guo, Yu
Liu, Xinfeng
Song, Yilin
Zhang, Ping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-28
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
1H NMR-based metabolic profiling combined with multivariate data analysis was used to explore the metabolic phenotype of functional dyspepsia (FD) in stressed rats and evaluate the intervention effects of the Chinese medicine Weikangning (WKN).
After a 7-day period of model establishment, a 14-day drug administration schedule was conducted in a WKN-treated group of rats, with the model and normal control groups serving as negative controls.
Based on 1H NMR spectra of urine and serum from rats, PCA, PLS-DA, and OPLS-DA were performed to identify changing metabolic profiles.
According to the key metabolites determined by OPLS-DA, alterations in energy metabolism, stress-related metabolism, and gut microbiota were found in FD model rats after stress stimulation, and these alterations were restored to normal after WKN administration.
This study may provide new insights into the relationship between FD and psychological stress and assist in research into the metabolic mechanisms involved in Chinese medicine.
American Psychological Association (APA)
Guo, Yu& Li, Zhongfeng& Liu, Xinfeng& Su, Xiao-Lan& Li, Yi-Jie& Zhu, Jia-Jie…[et al.]. 2017. 1H NMR-Based Metabonomic Study of Functional Dyspepsia in Stressed Rats Treated with Chinese Medicine Weikangning. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1153644
Modern Language Association (MLA)
Guo, Yu…[et al.]. 1H NMR-Based Metabonomic Study of Functional Dyspepsia in Stressed Rats Treated with Chinese Medicine Weikangning. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1153644
American Medical Association (AMA)
Guo, Yu& Li, Zhongfeng& Liu, Xinfeng& Su, Xiao-Lan& Li, Yi-Jie& Zhu, Jia-Jie…[et al.]. 1H NMR-Based Metabonomic Study of Functional Dyspepsia in Stressed Rats Treated with Chinese Medicine Weikangning. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1153644
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153644