Meta-Analysis of the Use of 8-OHdG in Saliva as a Marker of Periodontal Disease
Joint Authors
Almerich-Silla, Jose Manuel
Montiel-Company, Jose María
Paredes-Sánchez, Esther
Iranzo-Cortés, José Enrique
Almerich-Torres, Teresa
Bellot-Arcís, Carlos
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The objective was to collect the available evidence on oxidative stress marker measurements in periodontal patients, focusing specifically on 8-hydroxy-2′-deoxyguanosine (8-OHdG) as a salivary marker of periodontal disease, and to perform meta-analyses to calculate differences in concentration compared to healthy persons.
A systematic search in PubMed, Cochrane Library, Embase, and Scopus identified 81 articles.
Of these, 38 were duplicates.
After reading the abstracts of the remaining 43, 42 were selected for full-text assessment.
Finally, 17 articles were included in the qualitative synthesis.
Those excluded were of low quality, did not answer the research question, or did not meet the inclusion and exclusion criteria.
Of the 17 in the qualitative synthesis, 9 were included in the meta-analysis.
The 9 studies in the meta-analysis were combined in a random effects model.
Their heterogeneity was high (Q=3982.02, p<0.001, I2=99.8%).
The difference in mean 8-OHdG concentration in saliva between periodontal and healthy subjects was estimated at 2.11 ng/ml (95% CI 1.23–2.98).
The different saliva collection methods (stimulated/unstimulated) did not explain the heterogeneity.
The 8-OHdG levels in saliva of periodontal patients were almost double to those of healthy patients: 8-OHdG is clearly a powerful periodontal disease marker.
American Psychological Association (APA)
Paredes-Sánchez, Esther& Montiel-Company, Jose María& Iranzo-Cortés, José Enrique& Almerich-Torres, Teresa& Bellot-Arcís, Carlos& Almerich-Silla, Jose Manuel. 2018. Meta-Analysis of the Use of 8-OHdG in Saliva as a Marker of Periodontal Disease. Disease Markers،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1153671
Modern Language Association (MLA)
Paredes-Sánchez, Esther…[et al.]. Meta-Analysis of the Use of 8-OHdG in Saliva as a Marker of Periodontal Disease. Disease Markers No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1153671
American Medical Association (AMA)
Paredes-Sánchez, Esther& Montiel-Company, Jose María& Iranzo-Cortés, José Enrique& Almerich-Torres, Teresa& Bellot-Arcís, Carlos& Almerich-Silla, Jose Manuel. Meta-Analysis of the Use of 8-OHdG in Saliva as a Marker of Periodontal Disease. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1153671
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153671