Baseline Serum Uric Acid Levels Are Associated with All-Cause Mortality in Acute Coronary Syndrome Patients after Percutaneous Coronary Intervention

Abstract EN

Background.

Whether serum uric acid (UA) is associated with all-cause mortality in patients with acute coronary syndrome (ACS) following percutaneous coronary intervention (PCI) remains unclear.

Methods.

We performed a retrospective cohort study of 2296 patients with ACS.

Curve-fitting and Cox proportional-hazard regression models with a hazard ratio (HR) and 95% confidence interval (CI) were used.

Results.

During a mean follow-up of 246.31 ± 49.16 days, 168 (7.32%) patients died from all causes.

Patients were divided into two groups [the high-UA group (n=566) and the low-UA group (n=1730)] based on the serum UA threshold value (5.6 mg/dl) identified through curve fitting.

Fifty-three (9.36%) patients died in the high-UA group, and 115 (6.65%) patients died in the low-UA group.

The difference between groups was statistically significant (P=0.031).

Univariate analysis showed that the risk of all-cause mortality in the high-UA group was significantly greater than that in the low-UA group (HR = 1.45, 95% CI: 1.03 to 2.04).

This difference persisted after adjustment for baseline characteristics, medical history, and medication history (HR = 1.42, 95% CI: 1.05 to 1.87).

Conclusions.

Our study demonstrated that elevated serum UA (>5.6 mg/dl) is associated with all-cause mortality in ASC patients after PCI.