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Nyctanthes arbor-tristis Ameliorated FCA-Induced Experimental Arthritis: A Comparative Study among Different Extracts
Joint Authors
Uroos, Maliha
Abbas, Zaigham
Sattar, Shumaila
Umer, Nigarish
Shabbir, Arham
Shafiq-ur-Rehman, Arham
Sharif, Ahsan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-06
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Nyctanthes arbor-tristis (NAT) is commonly used traditionally for the treatment of rheumatism and inflammatory diseases.
Current study evaluates the antiarthritic potential of NAT using Freund’s adjuvant-induced arthritic rat model.
Treatments with methanolic, ethyl acetate, and n-hexane extracts were continued for consecutive 20 days.
Macroscopic arthritic scoring and water displacement plethysmometry were used to evaluate arthritic development.
Hematological and biochemical parameters were investigated and ankle joints were processed for histopathological evaluation.
Qualitative phytochemical analysis and GC-MS analysis were conducted for identification of constituents.
NAT extracts suppressed arthritic scoring, paw edema, infiltration of inflammatory cells, pannus formation, and bone erosion.
The plant extracts ameliorated total leukocytes and platelet counts and nearly normalized red blood cells (RBC) counts and hemoglobin (Hb) content.
The extracts were found safe in terms of hepatotoxicity and nephrotoxicity as determined by aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, and urea levels.
Comparative analysis showed that ethyl acetate extract produced the highest inhibition of paw edema.
The major constituents found in ethyl acetate extract can be classified into three major classes, that is, terpenes, terpenoids, fatty acids, and iridoid glycosides.
Current study showed that Nyctanthes arbor-tristis ameliorated experimental rheumatoid arthritis and ethyl acetate extract possessed the highest inhibitory activity.
American Psychological Association (APA)
Uroos, Maliha& Abbas, Zaigham& Sattar, Shumaila& Umer, Nigarish& Shabbir, Arham& Shafiq-ur-Rehman, Arham…[et al.]. 2017. Nyctanthes arbor-tristis Ameliorated FCA-Induced Experimental Arthritis: A Comparative Study among Different Extracts. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1153819
Modern Language Association (MLA)
Uroos, Maliha…[et al.]. Nyctanthes arbor-tristis Ameliorated FCA-Induced Experimental Arthritis: A Comparative Study among Different Extracts. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1153819
American Medical Association (AMA)
Uroos, Maliha& Abbas, Zaigham& Sattar, Shumaila& Umer, Nigarish& Shabbir, Arham& Shafiq-ur-Rehman, Arham…[et al.]. Nyctanthes arbor-tristis Ameliorated FCA-Induced Experimental Arthritis: A Comparative Study among Different Extracts. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1153819
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153819