A Simplified Diagnostic Classification Scheme of Chemotherapy-Induced Peripheral Neuropathy
Joint Authors
Lin, Chou-Ching K.
Wu, Pei-Ying
Su, Pei-Fang
Li, Chung-I
Yeh, Yu-Min
Lin, Peng-Chan
Hsu, Keng-Fu
Shen, Meng-Ru
Chang, Jang-Yang
Huang, Han-Wei
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background and Objective.
The main purpose of this study was to develop a simple automatic diagnostic classification scheme for chemotherapy-induced peripheral neuropathy.
Methods.
This was a prospective cohort study that enrolled patients with colorectal or gynecologic cancer post chemotherapy for more than 1 year.
The patients underwent laboratory examinations (nerve conduction studies and quantitative sensory tests), and a questionnaire about the quality of life.
An unsupervised classification algorithm was used to classify the patients into groups using a small number of variables derived from the laboratory tests.
A panel of five neurologists also diagnosed the types of neuropathies according to the laboratory tests.
The results by the unsupervised classification algorithm and the neurologists were compared.
Results.
The neurologists’ diagnoses showed much higher rates of entrapment syndromes (66.1%) and radiculopathies (55.1%) than polyneuropathy (motor/sensory: 33.1%/29.7%).
A multivariate analysis showed that the questionnaire was not significantly correlated with the results of quantitative sensory tests (r=0.27) or the neurologists’ diagnoses (r=0.2).
All of the patients were classified into four groups by the unsupervised classification algorithm.
The classification corresponded to the severity of neuropathy and correlated well with the neurologists’ diagnoses and the scales of neurological examinations.
The overall correct rate of classification by the unsupervised classification algorithm was 78.8% (95% confidence interval: 73.1%-88.3%).
Conclusion.
The results of our unsupervised classification algorithm based on three variables of laboratory tests correlated well with the neurologists’ diagnoses.
American Psychological Association (APA)
Huang, Han-Wei& Wu, Pei-Ying& Su, Pei-Fang& Li, Chung-I& Yeh, Yu-Min& Lin, Peng-Chan…[et al.]. 2020. A Simplified Diagnostic Classification Scheme of Chemotherapy-Induced Peripheral Neuropathy. Disease Markers،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1153820
Modern Language Association (MLA)
Huang, Han-Wei…[et al.]. A Simplified Diagnostic Classification Scheme of Chemotherapy-Induced Peripheral Neuropathy. Disease Markers No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1153820
American Medical Association (AMA)
Huang, Han-Wei& Wu, Pei-Ying& Su, Pei-Fang& Li, Chung-I& Yeh, Yu-Min& Lin, Peng-Chan…[et al.]. A Simplified Diagnostic Classification Scheme of Chemotherapy-Induced Peripheral Neuropathy. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1153820
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153820