Clinical Significance of C-Reactive Protein to Albumin Ratio in Patients with Hepatocellular Carcinoma: A Meta-Analysis
Joint Authors
Ke, Qiao
Cao, Yingping
Lin, Nanping
Li, Jingrong
Wang, Lei
Liu, Jingfeng
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
To evaluate the prognostic significance of C-reactive protein to albumin ratio (CAR) for clinical outcomes in hepatocellular carcinoma (HCC) patients.
Material and Methods.
Eligible studies were searched by PubMed, MedLine, the Cochrane Library, from January 1, 2000, to June 30, 2019, investigating the prognostic value of CAR in patients with HCC.
Primary endpoint was OS.
Hazard ratio (HR) with 95% confidence interval (CI) was used to determine the effect size.
Results.
7 records including 2208 patients published since 2014 were enrolled into our meta-analysis.
Clinicopathological characteristics were also correlated with the level of CAR.
The pooled HR for the OS rate between low and high CAR groups was 2.13 (95% CI 1.70~2.68, P<0.00001) using a random model, but sensitivity analysis showed that the pooled HR for the OS rates did not change substantially after removal of any included study.
As for patients receiving surgery, the pooled HR for the OS rate between low and high CAR groups was 2.04 (95% CI 1.59~2.61, P<0.00001).
Subgroup analysis showed that CAR could be a prognostic biomarker for HCC patients regardless of regions (China, HR=1.75, 95% CI 1.51~2.02; Japan, HR=3.36, 95% CI 2.07~5.45; Korea, HR=2.26, 95% CI 1.47~4.47; respectively), the cut-off value (<0.1, HR=2.84, 95% CI 1.90~4.24; >0.1, HR=1.99, 95% CI 1.52~2.61; respectively), and sample size (<200, HR=2.85, 95% CI 2.01~4.03; >200, HR=1.75, 95% CI 1.52~2.02; respectively).
Conclusion.
With the current data, we clearly concluded that CAR was closely correlated with prognosis of patients with HCC.
Multicenter, prospective randomized trials are warranted to confirm the conclusion.
American Psychological Association (APA)
Lin, Nanping& Li, Jingrong& Ke, Qiao& Wang, Lei& Cao, Yingping& Liu, Jingfeng. 2020. Clinical Significance of C-Reactive Protein to Albumin Ratio in Patients with Hepatocellular Carcinoma: A Meta-Analysis. Disease Markers،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1153863
Modern Language Association (MLA)
Lin, Nanping…[et al.]. Clinical Significance of C-Reactive Protein to Albumin Ratio in Patients with Hepatocellular Carcinoma: A Meta-Analysis. Disease Markers No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1153863
American Medical Association (AMA)
Lin, Nanping& Li, Jingrong& Ke, Qiao& Wang, Lei& Cao, Yingping& Liu, Jingfeng. Clinical Significance of C-Reactive Protein to Albumin Ratio in Patients with Hepatocellular Carcinoma: A Meta-Analysis. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1153863
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153863