Apolipoprotein E Gene Polymorphism, Glycated Hemoglobin, and Peripheral Arterial Disease Risk in Chinese Type 2 Diabetic Patients
Joint Authors
Feng, Tongbao
Hu, Yujing
Ling, Tinghuan
Yu, Min
Bai, Yang
Zhang, Ping
Wang, Yan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
The apolipoprotein E (ApoE) gene polymorphism has been found to influence plasma lipid concentration, and its correlation with peripheral arterial disease (PAD) has been investigated.
However, it is unclear whether ApoE is associated with PAD in Chinese type 2 diabetes mellitus (T2DM) patients.
Therefore, our study is aimed at investigating the relationship between the ApoE gene polymorphism and PAD in Chinese T2DM patients.
Methods.
A total of 192 T2DM patients were divided into two groups: T2DM and T2DM with PAD.
The clinical and biochemical parameters were obtained.
Polymerase chain reaction was used to identify the genotypes of ApoE.
The multivariable logistic regression analysis was used to identify the possible risk factor for PAD.
Results.
There were no significant differences in the genotype and allele frequencies of ApoE between the T2DM and T2DM with PAD groups.
However, the T2DM with PAD group tended to have more ε4/ε3 genotypes (21.5% vs.
11.3%) than the T2DM group.
The multivariate logistic regression showed that smoking, age, disease duration, TG, LDL, and HbA1c were risk factors for PAD.
Conclusions.
These results demonstrated that there was no evidence of a relationship between ApoE and PAD.
American Psychological Association (APA)
Hu, Yujing& Ling, Tinghuan& Yu, Min& Bai, Yang& Feng, Tongbao& Zhang, Ping…[et al.]. 2020. Apolipoprotein E Gene Polymorphism, Glycated Hemoglobin, and Peripheral Arterial Disease Risk in Chinese Type 2 Diabetic Patients. Disease Markers،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1153910
Modern Language Association (MLA)
Hu, Yujing…[et al.]. Apolipoprotein E Gene Polymorphism, Glycated Hemoglobin, and Peripheral Arterial Disease Risk in Chinese Type 2 Diabetic Patients. Disease Markers No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1153910
American Medical Association (AMA)
Hu, Yujing& Ling, Tinghuan& Yu, Min& Bai, Yang& Feng, Tongbao& Zhang, Ping…[et al.]. Apolipoprotein E Gene Polymorphism, Glycated Hemoglobin, and Peripheral Arterial Disease Risk in Chinese Type 2 Diabetic Patients. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1153910
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153910