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Effects of Achyrocline satureioides Inflorescence Extracts against Pathogenic Intestinal Bacteria: Chemical Characterization, In Vitro Tests, and In Vivo Evaluation
Joint Authors
Gelain, Daniel Pens
Brandelli, Adriano
Bassani, Valquíria Linck
Moresco, Karla Suzana
Silveira, Alexandre Kleber
Oliveria, Rafael R.
Borges, Adriana Giongo
Grun, Lucas
Barbé-Tuana, Florencia
Zmozinski, Ariane
Vale, Maria Goretti Rodrigues
Corrêa, Ana Paula Folmer
Zeidán-Chuliá, Fares
Fonseca Moreira, José Cláudio
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Three Achyrocline satureioides (AS) inflorescences extracts were characterized: (i) a freeze-dried extract prepared from the aqueous extractive solution and (ii) a freeze-dried and (iii) a spray-dried extract prepared from hydroethanol extractive solution (80% ethanol).
The chemical profile, antioxidant potential, and antimicrobial activity against intestinal pathogenic bacteria of AS extracts were evaluated.
In vitro antioxidant activity was determined by the total reactive antioxidant potential (TRAP) assay.
In vivo analysis and characterization of intestinal microbiota were performed in male Wistar rats (saline versus treated animals with AS dried extracts) by high-throughput sequencing analysis: metabarcoding.
Antimicrobial activity was tested in vitro by the disc diffusion tests.
Moisture content of the extracts ranged from 10 to 15% and 5.7 to 17 mg kg−1 of fluorine.
AS exhibited antioxidant activity, especially in its freeze-dried form which also exhibited a wide spectrum of antimicrobial activity against intestinal pathogenic bacteria greater than those observed by the antibiotic, amoxicillin, when tested against Bacillus cereus and Staphylococcus aureus.
Antioxidant and antimicrobial activities of AS extracts seemed to be positively correlated with the present amount of flavonoids.
These findings suggest a potential use of AS as a coadjuvant agent for treating bacterial-induced intestinal diseases with high rates of antibiotic resistance.
American Psychological Association (APA)
Moresco, Karla Suzana& Silveira, Alexandre Kleber& Zeidán-Chuliá, Fares& Corrêa, Ana Paula Folmer& Oliveria, Rafael R.& Borges, Adriana Giongo…[et al.]. 2017. Effects of Achyrocline satureioides Inflorescence Extracts against Pathogenic Intestinal Bacteria: Chemical Characterization, In Vitro Tests, and In Vivo Evaluation. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153913
Modern Language Association (MLA)
Moresco, Karla Suzana…[et al.]. Effects of Achyrocline satureioides Inflorescence Extracts against Pathogenic Intestinal Bacteria: Chemical Characterization, In Vitro Tests, and In Vivo Evaluation. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1153913
American Medical Association (AMA)
Moresco, Karla Suzana& Silveira, Alexandre Kleber& Zeidán-Chuliá, Fares& Corrêa, Ana Paula Folmer& Oliveria, Rafael R.& Borges, Adriana Giongo…[et al.]. Effects of Achyrocline satureioides Inflorescence Extracts against Pathogenic Intestinal Bacteria: Chemical Characterization, In Vitro Tests, and In Vivo Evaluation. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153913
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153913