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Effects of Electroacupuncture on Methamphetamine-Induced Behavioral Changes in Mice
Joint Authors
Chiang, Yao-Chang
Ho, Tsung-Jung
Lee, Chiang-Wen
Lu, Zi-Yun
Tsai, Ming-Horng
Ho, Ing-Kang
Huang, Chieh-Liang
Lane, Hsien-Yuan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Methamphetamine (METH) is a major drug of abuse worldwide, and no efficient therapeutic strategies for treating METH addiction are currently available.
Continuous METH use can cause behavioral upregulation or psychosis.
The dopaminergic pathways, particularly the neural circuitry from the ventral tegmental area to the nucleus accumbens (NAc), have a critical role in this behavioral stage.
Acupuncture has been used for treating diseases in China for more than 2000 years.
According to a World Health Organization report, acupuncture can be used to treat several functional disorders, including substance abuse.
In addition, acupuncture is effective against opioids addiction.
In this study, we used electroacupuncture (EA) for treating METH-induced behavioral changes and investigated the possible therapeutic mechanism.
Results showed that EA at the unilateral Zhubin (KI9)–Taichong (LR3) significantly reduced METH-induced behavioral sensitization and conditioned place preference.
In addition, both dopamine and tyrosine hydroxylase (TH) levels decreased but monoamine oxidase A (MAO-A) levels increased in the NAc of the METH-treated mice receiving EA compared with those not receiving EA.
EA may be a useful nonpharmacological approach for treating METH-induced behavioral changes, probably because it reduces the METH-induced TH expression and dopamine levels and raises MAO-A expression in the NAc.
American Psychological Association (APA)
Ho, Tsung-Jung& Lee, Chiang-Wen& Lu, Zi-Yun& Lane, Hsien-Yuan& Tsai, Ming-Horng& Ho, Ing-Kang…[et al.]. 2017. Effects of Electroacupuncture on Methamphetamine-Induced Behavioral Changes in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1154088
Modern Language Association (MLA)
Ho, Tsung-Jung…[et al.]. Effects of Electroacupuncture on Methamphetamine-Induced Behavioral Changes in Mice. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1154088
American Medical Association (AMA)
Ho, Tsung-Jung& Lee, Chiang-Wen& Lu, Zi-Yun& Lane, Hsien-Yuan& Tsai, Ming-Horng& Ho, Ing-Kang…[et al.]. Effects of Electroacupuncture on Methamphetamine-Induced Behavioral Changes in Mice. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1154088
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154088