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Zanthoxylum heitzii Modulates Ferric Nitrilotriacetate-Dependent Oxidative Alterations in Four Vital Organs: An In Vitro Organoprotective Model
Joint Authors
Moukette, Bruno Moukette
Pieme, Anatole Constant
Joël Essogo, Jacques
Tankeu, Francine Nzufo
Nanfack, Pauline
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Ferric nitrilotriacetate (Fe-NTA) is a highly reactive compound used to induce degenerative disorders through oxidative stress (OS).
Zanthoxylum heitzii (Z.
heitzii) is a spice used as a medicinal plant to treat a variety of illnesses.
This study investigated the ability of extracts from the leaves, fruits, roots, and barks of Z.
Heitzii to inhibit Fe-NTA mediated oxidative damage in rats.
The supernatant of rat liver homogenates was pretreated with the extracts for one hour before the induction of oxidative damage using a solution of Fe-NTA (400 mM).
The activities of superoxide dismutase (SOD), catalase, and peroxidases were measured together with the marker of lipid peroxidation and the level of glutathione.
The pretreated groups showed a significant increase in the activity of SOD, catalase, and peroxidases.
The methanolic extract from the leaves of Z.
heitzii (36.78 ± 3.30) and aqueous extract from the fruits (37.01 ± 2.52) showed the highest activities of SOD in the liver.
The lowest concentration of MDA was found in the liver, and the glutathione was greater in the brain.
Conclusively, these results suggest that Z.
heitzii might be a chemoprotector which may be used in for prevention of distinct types of diseases induced by oxidative stress.
American Psychological Association (APA)
Joël Essogo, Jacques& Moukette, Bruno Moukette& Tankeu, Francine Nzufo& Nanfack, Pauline& Pieme, Anatole Constant. 2017. Zanthoxylum heitzii Modulates Ferric Nitrilotriacetate-Dependent Oxidative Alterations in Four Vital Organs: An In Vitro Organoprotective Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1154189
Modern Language Association (MLA)
Joël Essogo, Jacques…[et al.]. Zanthoxylum heitzii Modulates Ferric Nitrilotriacetate-Dependent Oxidative Alterations in Four Vital Organs: An In Vitro Organoprotective Model. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1154189
American Medical Association (AMA)
Joël Essogo, Jacques& Moukette, Bruno Moukette& Tankeu, Francine Nzufo& Nanfack, Pauline& Pieme, Anatole Constant. Zanthoxylum heitzii Modulates Ferric Nitrilotriacetate-Dependent Oxidative Alterations in Four Vital Organs: An In Vitro Organoprotective Model. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1154189
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154189