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Antioxidant, Antiglycation, and Hypoglycaemic Effect of Seriphium plumosum Crude Plant Extracts
Joint Authors
Mampuru, Leseilane
Mokgotho, Matlou Phineas
Bagla, V. P.
Beseni, Brian K.
Njanje, Idris
Matsebatlela, Thabe M.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Diabetes is a severely debilitating metabolic disorder characterised by chronic hyperglycaemia.
Traditional medicinal plants provide an important avenue for the development of novel antidiabetic agents.
The antidiabetic potential of the methanol, acetone, and hexane extracts of S.
plumosum was assessed using different parameters.
These included secondary metabolite quantification, hypoglycaemic, cytotoxic effects, and GLUT4 translocation augmentation on C2C12 cells.
The methanol extract contained the highest amount of total phenolic and flavonoid compounds and showed enhanced antioxidant activity.
The methanol extracts had the best DPPH scavenging (EC50 = 0.72 mg/ml) and ferric reducing powers (EC50 = 2.31 mg/ml).
The hexane extract resulted in the highest glucose uptake activity of 35, 77% with respect to all other treatments after a 6-hour exposure period.
Immunocytochemistry technique further revealed that the increased glucose utilisation may be due to increased membrane fused GLUT4 molecules in C2C12 cells.
The hexane extract was also shown to upregulate the phosphorylation of p70 S6 kinase and Akt1/2.
The study highlights a probable insulin-mimetic activity of the hexane extract via the augmentation of Akt1/2 phosphorylation which is involved in the GLUT4 translocation pathway.
Furthermore, the study represents the first report on the cytotoxic effect, GLUT4 translocation, and glucose uptake potential of S.
plumosum.
American Psychological Association (APA)
Beseni, Brian K.& Bagla, V. P.& Njanje, Idris& Matsebatlela, Thabe M.& Mampuru, Leseilane& Mokgotho, Matlou Phineas. 2017. Antioxidant, Antiglycation, and Hypoglycaemic Effect of Seriphium plumosum Crude Plant Extracts. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1154336
Modern Language Association (MLA)
Beseni, Brian K.…[et al.]. Antioxidant, Antiglycation, and Hypoglycaemic Effect of Seriphium plumosum Crude Plant Extracts. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1154336
American Medical Association (AMA)
Beseni, Brian K.& Bagla, V. P.& Njanje, Idris& Matsebatlela, Thabe M.& Mampuru, Leseilane& Mokgotho, Matlou Phineas. Antioxidant, Antiglycation, and Hypoglycaemic Effect of Seriphium plumosum Crude Plant Extracts. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1154336
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154336