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Skin Wound Healing Potential and Mechanisms of the Hydroalcoholic Extract of Leaves and Oleoresin of Copaifera langsdorffii Desf. Kuntze in Rats
Joint Authors
Bastos, Jairo Kennup
Hussni, Carlos Alberto
Rozza, A. L.
Gushiken, Lucas Fernando Sérgio
Beserra, Fernando Pereira
Vieira, Ana Júlia
Padovani, Carlos Roberto
Lemos, Marivane
Polizello Junior, Maurilio
Silva, Jonas Joaquim Mangabeira da
Nóbrega, Rafael Henrique
Martinez, Emanuel Ricardo Monteiro
Pellizzon, Cláudia Helena
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-27
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The wound healing is a complex process which, sometimes, can be a problem in public health because of the possibility of physical disability or even death.
Due to the lack of a gold standard drug in skin wound treatment and aiming at the discovery of new treatments in skin repair and the mechanisms involved in the process, we used oleoresin (OR) from Copaifera langsdorffii and hydroalcoholic extract of the leaves (EH) to treat rat skin wounds.
For that, male Wistar rats were divided into groups (n=8): Lanette, Collagenase, 10% EH, or 10% OR and, after anesthesia, one wound of 2 cm was made in the back of animals.
The wounds were treated once a day for 3, 7, or 14 days and the wound areas were measured.
The rats were euthanized and skin samples destined to biochemical, molecular, and immunohistochemical analysis.
The results showed a macroscopic retraction of the wounds of 10% EH and 10% OR creams and both treatments showed anti-inflammatory activity.
Molecular and immunohistochemical results demonstrated the activity of Copaifera langsdorffii creams in angiogenesis, reepithelialization, wound retraction, and remodeling mechanisms.
American Psychological Association (APA)
Gushiken, Lucas Fernando Sérgio& Hussni, Carlos Alberto& Bastos, Jairo Kennup& Rozza, A. L.& Beserra, Fernando Pereira& Vieira, Ana Júlia…[et al.]. 2017. Skin Wound Healing Potential and Mechanisms of the Hydroalcoholic Extract of Leaves and Oleoresin of Copaifera langsdorffii Desf. Kuntze in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1154370
Modern Language Association (MLA)
Gushiken, Lucas Fernando Sérgio…[et al.]. Skin Wound Healing Potential and Mechanisms of the Hydroalcoholic Extract of Leaves and Oleoresin of Copaifera langsdorffii Desf. Kuntze in Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1154370
American Medical Association (AMA)
Gushiken, Lucas Fernando Sérgio& Hussni, Carlos Alberto& Bastos, Jairo Kennup& Rozza, A. L.& Beserra, Fernando Pereira& Vieira, Ana Júlia…[et al.]. Skin Wound Healing Potential and Mechanisms of the Hydroalcoholic Extract of Leaves and Oleoresin of Copaifera langsdorffii Desf. Kuntze in Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1154370
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154370