The Effect of a Hydrolyzed Polysaccharide Dietary Supplement on Biomarkers in Adults with Nonalcoholic Fatty Liver Disease
Joint Authors
Mendez, A. J.
Lewis, John E.
Atlas, Steven E.
Higuera, Oscar L.
Fiallo, Andrea
Rasul, Ammar
Farooqi, Ashar
Kromo, Olga
Lantigua, Laura A.
Tiozzo, Eduard
Woolger, Judi M.
Goldberg, Sharon
Rodriguez, Allan E.
Konefal, Janet
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The primary objective of the study was to evaluate the effect of a hydrolyzed polysaccharide, Rice Bran Arabinoxylan Compound (RBAC), on biomarkers in adults with nonalcoholic fatty liver disease (NAFLD).
A 90-day randomized double-blind placebo-controlled trial examined the effect of RBAC on complete blood count, liver enzymes, lipids, oxidative stress markers, cytokines, and growth factors.
Twenty-three adults with NAFLD were enrolled and randomly assigned to one of the two study conditions (n=12 RBAC and n=11 placebo) and consumed 1 gram/day of either compound for 90 days.
Subjects were assessed at baseline and 45 and 90 days.
No adverse effects were reported.
Alkaline phosphatase significantly decreased (−3.1%; SD=19.9; F[1,19]=5.1, p=0.03) in the RBAC group compared to the placebo group.
The percentages of monocytes (17.9%; SD=18.3; F[1,19]=5.9, p=0.02) and eosinophils (30.6%; SD=30.5; F[1,19]=12.3, p<0.01) increased in the RBAC group.
IFN-γ (156%; SD=131.8; F[1,19]=4.2, p=0.06) and IL-18 (29.1%; SD=64; F[1,19]=5.3, p=0.03) increased in the RBAC group compared to the placebo group.
Other improvements were noted for platelets, neutrophils, neutrophil-lymphocyte ratio, γ-glutamyl transferase, and 4-hydroxynonenal.
RBAC had beneficial effects on several biomarkers that adds to the known immunomodulatory activities of RBAC, which may be promising for people with NAFLD.
American Psychological Association (APA)
Lewis, John E.& Atlas, Steven E.& Higuera, Oscar L.& Fiallo, Andrea& Rasul, Ammar& Farooqi, Ashar…[et al.]. 2018. The Effect of a Hydrolyzed Polysaccharide Dietary Supplement on Biomarkers in Adults with Nonalcoholic Fatty Liver Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154466
Modern Language Association (MLA)
Lewis, John E.…[et al.]. The Effect of a Hydrolyzed Polysaccharide Dietary Supplement on Biomarkers in Adults with Nonalcoholic Fatty Liver Disease. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1154466
American Medical Association (AMA)
Lewis, John E.& Atlas, Steven E.& Higuera, Oscar L.& Fiallo, Andrea& Rasul, Ammar& Farooqi, Ashar…[et al.]. The Effect of a Hydrolyzed Polysaccharide Dietary Supplement on Biomarkers in Adults with Nonalcoholic Fatty Liver Disease. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154466
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154466