Antiproliferative and Antibacterial Activities of Cirsium scabrum from Tunisia
Joint Authors
Sahpaz, Sevser
Quetin-Leclercq, Joëlle
Sahli, Ramla
Dufloer, Cédric
Beaufay, Claire
Bero, Joanne
Ksouri, Riadh
Roumy, Vincent
Rivière, Céline
Neut, Christel
Hennebelle, Thierry
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Several Cirsium species are known for their uses in traditional medicine and consequently are studied for their phytochemical content and their biological activities.
In the framework of a previous study conducted on eight extremophile plants from Tunisia, we highlighted that the crude methanolic extract of C.
scabrum, a not investigated thistle, showed moderate but quite selective cytotoxic activity against the cancerous cell line J774 compared to the noncancerous cell line WI38 (IC50 = 11.53 μg/ml on J774, IC50 = 29.89 µg/ml on WI38, and selectivity index = 2.6).
In the current study, the partitions of the leaves of C.
scabrum were analyzed for their antiproliferative activity on the same cell lines.
From the most active petroleum ether partition, we isolated four triterpenoids including lupeol, taraxasterol acetate, and a (1 : 1) mixture of 25-hydroperoxycycloart-23-en-3β-ol and 24-hydroperoxycycloart-25-en-3β-ol.
These two cycloartane-type triterpenoids are mostly responsible for this cytotoxic activity.
On the other hand, the antimicrobial potential of this plant was also evaluated against 36 microorganisms.
The moderate antibacterial activity against 6 Staphylococcus aureus and 2 Dermabacter hominis strains is mainly attributed to the butanol partition whose major compounds are glycosides of flavones.
American Psychological Association (APA)
Sahli, Ramla& Rivière, Céline& Dufloer, Cédric& Beaufay, Claire& Neut, Christel& Bero, Joanne…[et al.]. 2017. Antiproliferative and Antibacterial Activities of Cirsium scabrum from Tunisia. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1154486
Modern Language Association (MLA)
Sahli, Ramla…[et al.]. Antiproliferative and Antibacterial Activities of Cirsium scabrum from Tunisia. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1154486
American Medical Association (AMA)
Sahli, Ramla& Rivière, Céline& Dufloer, Cédric& Beaufay, Claire& Neut, Christel& Bero, Joanne…[et al.]. Antiproliferative and Antibacterial Activities of Cirsium scabrum from Tunisia. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1154486
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154486