Regulating the Balance of Th17Treg via Electroacupuncture and Moxibustion: An Ulcerative Colitis Mice Model Based Study
Joint Authors
Yang, Ming-Xiao
Wu, Qiaofeng
Wang, Xiang
Yu, Shu-guang
Zhuang, Zhiqi
Sun, Jungang
Zhang, Hejiaozi
Wang, Chengyulin
Chang, Shyang
Geng, Yu
Yang, Hui
Xie, Lushuang
Huang, Biao
Zhao, Na
Zhou, Wei
Cheng, Xinhui
Cai, Bei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Aim.
To investigate the relationship between the effects of electroacupuncture/moxibustion and the balance of Th17/Treg in treating ulcerative colitis (UC) and to preliminary compare the effects of the above two methods.
Methods.
DSS-induced UC mice were treated by electroacupuncture and moxibustion.
Disease activity index (DAI) was scored; intestinal pathological structure and ultrastructure were observed.
The levels of IL-2, IL-6, IL-10, IL-17A, IL-17F, and TGF-β in plasma were measured by ELISA.
The percentages of Treg and Th17 in spleen lymphocytes were analyzed by flow cytometry.
Also, the expressions of TLR2, TLR4, RORγt, and FOXP3 in the distal colon were detected by immunohistochemistry or western blot.
Results.
Both electroacupuncture and moxibustion can relieve UC.
These effects are further supported by ELISA results.
In addition, the ratio of Treg and Th17 in spleen lymphocytes and the expression of TLR2 and TLR4 are significantly improved.
Also, the expression of RORγt and FOXP3 in distal colon were improved.
Besides, the effect of moxibustion is better than that of electroacupuncture on TLR2, TLR4, and FOXP3 expression (P<0.05).
Conclusion.
Both electroacupuncture and moxibustion may ameliorate UC by regulating the balance of Th17/Treg.
Whether moxibustion has better efficacy than electroacupuncture needs further study.
American Psychological Association (APA)
Sun, Jungang& Zhang, Hejiaozi& Wang, Chengyulin& Yang, Ming-Xiao& Chang, Shyang& Geng, Yu…[et al.]. 2017. Regulating the Balance of Th17Treg via Electroacupuncture and Moxibustion: An Ulcerative Colitis Mice Model Based Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1154500
Modern Language Association (MLA)
Sun, Jungang…[et al.]. Regulating the Balance of Th17Treg via Electroacupuncture and Moxibustion: An Ulcerative Colitis Mice Model Based Study. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1154500
American Medical Association (AMA)
Sun, Jungang& Zhang, Hejiaozi& Wang, Chengyulin& Yang, Ming-Xiao& Chang, Shyang& Geng, Yu…[et al.]. Regulating the Balance of Th17Treg via Electroacupuncture and Moxibustion: An Ulcerative Colitis Mice Model Based Study. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1154500
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154500