Optimal Dose of Epidural Dexmedetomidine Added to Ropivacaine for Epidural Labor Analgesia: A Pilot Study
Joint Authors
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-01
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Dexmedetomidine combined with local anesthetics can decrease the concentration of epidural ropivacaine.
However, the optimal dose of epidural dexmedetomidine combined with ropivacaine for labor analgesia is still uncertain.
This study investigated the effect of adding different dose of epidural dexmedetomidine to ropivacaine during epidural labor analgesia.
Methods.
One hundred women were randomly assigned to one of the four groups (Groups A, B, C, and D received 0.25, 0.5, 0.75, and 1 μg/ml of dexmedetomidine plus 0.1% ropivacaine, resp.).
The onset of epidural anesthesia and stages of labor were studied, and pain was assessed using a visual analogue scale (VAS).
Hemodynamic parameters and fetal heart rate were monitored.
Apgar scores and umbilical artery pH were recorded.
The side effects, if any, were recorded also.
Results.
The addition of 0.25, 0.5, and 0.75 μg/ml of dexmedetomidine to 0.1% ropivacaine provided safe and effective analgesia, but 1 μg/ml of dexmedetomidine resulted in increasing incidence of motor block.
The hemodynamic parameters were similar between groups (P>0.05).
Side effects in Group D were significantly higher than those in the other three groups (P<0.05).
Conclusions.
When dexmedetomidine is combined with 0.1% ropivacaine, the optimal concentration of dexmedetomidine is 0.5 μg/ml for epidural labor analgesia (this trial is registered with ChiCTR-OPC-16008548).
American Psychological Association (APA)
Wangping, Zhang& Ming, Ren. 2017. Optimal Dose of Epidural Dexmedetomidine Added to Ropivacaine for Epidural Labor Analgesia: A Pilot Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1154631
Modern Language Association (MLA)
Wangping, Zhang& Ming, Ren. Optimal Dose of Epidural Dexmedetomidine Added to Ropivacaine for Epidural Labor Analgesia: A Pilot Study. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1154631
American Medical Association (AMA)
Wangping, Zhang& Ming, Ren. Optimal Dose of Epidural Dexmedetomidine Added to Ropivacaine for Epidural Labor Analgesia: A Pilot Study. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1154631
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154631