Assessing the Risk Factors for Refractory Eosinophilic Esophagitis in Children and Adults
Joint Authors
Incorvaia, Cristoforo
Ridolo, Erminia
Martignago, Irene
Pellicelli, Irene
Source
Gastroenterology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Up to one-third of the patients suffering from eosinophilic esophagitis (EoE) present a refractory form, as defined by nonresponsiveness in clinical, endoscopic, or histological assessment after first-line therapy.
Several studies recently investigated which factors can influence the development of this disease, but very few analyzed the factors underlying refractory EoE.
Methods.
Medical charts of patients affected by EoE were retrospectively evaluated.
Phenotyping of patients was conducted according to demographic, clinical, histological, and treatment variables.
Then, patients were divided into responder and nonresponder to therapy and distinguished among children and adults.
Results.
Forty-five children and 35 adult EoE patients were included.
In the pediatric population, female sex (p<0.05) and a higher score of visual analogue scale (VAS) at the follow-up visit (p=0.02) were significantly associated to the risk of refractory EoE.
Among adults, statistical significance was reached for years of follow-up (p=0.001), diagnostic delay (p=0.03), use of antibiotics during infancy (p=0.01), and food allergy (p=0.04).
Conclusions.
Our study highlighted female sex and a higher VAS score at the time of follow-up visits as risk factors for refractory EoE in children, while the risk factors in adults were identified as fewer years of follow-up, greater diagnostic delay, use of antibiotics during infancy, and food allergy.
American Psychological Association (APA)
Ridolo, Erminia& Martignago, Irene& Pellicelli, Irene& Incorvaia, Cristoforo. 2019. Assessing the Risk Factors for Refractory Eosinophilic Esophagitis in Children and Adults. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1154826
Modern Language Association (MLA)
Ridolo, Erminia…[et al.]. Assessing the Risk Factors for Refractory Eosinophilic Esophagitis in Children and Adults. Gastroenterology Research and Practice No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1154826
American Medical Association (AMA)
Ridolo, Erminia& Martignago, Irene& Pellicelli, Irene& Incorvaia, Cristoforo. Assessing the Risk Factors for Refractory Eosinophilic Esophagitis in Children and Adults. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1154826
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154826