Garidisan: Improving the Quality of Ulcer Healing in Rats with Ulcerative Colitis
Joint Authors
Wang, Lin
Liu, Wei-Zhi
Pei, Ling-Yan
Ke, Yu-Shi
Cui, Jian
Li, Shu-Chun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Garidisan, commonly used in Mongolia to treat ulcerative colitis (UC), contains wild poppy and Artemisia frigida Willd.
Clinical evidence shows that Garidisan can effectively treat UC and that recurrence is low.
Thus, we evaluated the effects of Garidisan on ulcer healing quality and the regulation of immune balance in rats with experimental UC.
UC was induced by immunization with TNBS and Garidisan significantly reduced DAI, CMDI, and HS.
H&E staining, SEM, and VG staining showed that Garidisan repaired damaged intestinal mucosa and significantly reduced expression of ICAM-1 and CD105 in regenerated tissues of UC rats.
Collagen fibers were significantly fewer as well after treatment.
Garidisan elevated EGF, VEGF, bFGF, VEGFR2, and FGFR1 of UC rats, reduced CD3+CD4+/CD3+CD8+ T cell ratios, and increased CD4+Th1/CD4+Th2 cell ratios and IFN-r/IL-4 ratios in peripheral blood of UC rats.
In conclusion, Garidisan promoted tissue maturation of regenerated tissues by regulating the immune balance and improved functional maturity of regenerated tissues by reducing collagen formation, promoting maturation of new blood vessels, and increasing expression of growth factors and their receptors.
American Psychological Association (APA)
Wang, Lin& Liu, Wei-Zhi& Pei, Ling-Yan& Ke, Yu-Shi& Cui, Jian& Li, Shu-Chun. 2017. Garidisan: Improving the Quality of Ulcer Healing in Rats with Ulcerative Colitis. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154831
Modern Language Association (MLA)
Wang, Lin…[et al.]. Garidisan: Improving the Quality of Ulcer Healing in Rats with Ulcerative Colitis. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1154831
American Medical Association (AMA)
Wang, Lin& Liu, Wei-Zhi& Pei, Ling-Yan& Ke, Yu-Shi& Cui, Jian& Li, Shu-Chun. Garidisan: Improving the Quality of Ulcer Healing in Rats with Ulcerative Colitis. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154831
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154831