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Efficacy of Propolis on the Denture Stomatitis Treatment in Older Adults: A Multicentric Randomized Trial
Joint Authors
Berretta, Andresa Aparecida
Martins, Vicente P.
de Campos, Tatiana Amabile
Pina, Gisela de M. S.
Lia, Erica N.
Torres, Elina C.
Buszinski, Andrei F. M.
Coelho, Eduardo Barbosa
Rodrigues, Andresa Piacezzi Nascimento
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Our hypothesis tested the efficacy and safety of a mucoadhesive oral gel formulation of Brazilian propolis extract compared to miconazole oral gel for the treatment of denture stomatitis due to Candida spp.
infection in older adults.
Forty patients were randomly allocated in a noninferiority clinical trial into two groups.
The control group (MIC) received 20 mg/g miconazole oral gel and the study group (PROP) received mucoadhesive formulation containing standardized extract of 2% (20 mg/g) propolis (EPP-AF®) during 14 days.
Patients were examined on days 1, 7, and 14.
The Newton’s score was used to classify the severity of denture stomatitis.
The colony forming unity count (CFU/mL) was quantified and identified (CHROMagar Candida®) before and after the treatment.
Baseline characteristics did not differ between groups.
Both treatments reduced Newton’s score (P<0.0001), indicating a clinical improvement of the symptoms of candidiasis with a clinical cure rate of 70%.
The microbiological cure with significant reduction in fungal burden on T14 was 70% in the miconazole group and 25% in the EPP-AF group.
The EPP-AF appears to be noninferior to miconazole considering the clinical cure rate and could be recommended as an alternative treatment in older patients.
American Psychological Association (APA)
Pina, Gisela de M. S.& Lia, Erica N.& Berretta, Andresa Aparecida& Rodrigues, Andresa Piacezzi Nascimento& Torres, Elina C.& Buszinski, Andrei F. M.…[et al.]. 2017. Efficacy of Propolis on the Denture Stomatitis Treatment in Older Adults: A Multicentric Randomized Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1154870
Modern Language Association (MLA)
Pina, Gisela de M. S.…[et al.]. Efficacy of Propolis on the Denture Stomatitis Treatment in Older Adults: A Multicentric Randomized Trial. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1154870
American Medical Association (AMA)
Pina, Gisela de M. S.& Lia, Erica N.& Berretta, Andresa Aparecida& Rodrigues, Andresa Piacezzi Nascimento& Torres, Elina C.& Buszinski, Andrei F. M.…[et al.]. Efficacy of Propolis on the Denture Stomatitis Treatment in Older Adults: A Multicentric Randomized Trial. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1154870
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154870