Comparison of Polyethylene Glycol versus Lactulose Oral Solution for Bowel Preparation prior to Colonoscopy
Joint Authors
Xiao, Qiansong
Chen, Dongfeng
Guo, Yan
Li, Chun-Xia
Zhu, Yang-Jie
Zhu, Jian-Ru
Lan, Chun-Hui
Source
Gastroenterology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
This study was conducted to compare a lactulose oral solution with a polyethylene glycol (PEG) formulation for colonoscopy preparation using the following metrics: quality of cleansing, colonoscopy outcomes, patient/physician satisfaction, and patient tolerability.
Methods.
The enrolled patients were randomly divided into two groups and received a single 2 L dose of either PEG (PEG group) or lactulose (Lac group).
The Boston Bowel Preparation Scale (BBPS) was used for assessing the cleansing quality of the bowel preparations.
Patient tolerability and adverse events were obtained through the completion of questionnaires.
Results.
The lactulose oral solution showed superior bowel cleansing compared to PEG, as evidenced by higher BBPS scores in the Lac group for all segments of the colon (P<0.05).
The detection rates of polyps and intestinal lesions in the Lac group (30.68% and 36.36%, respectively) were significantly higher than those in the PEG group (12.50% vs.
13.63%, respectively).
For the degree of satisfaction, the Lac group had significantly higher scores compared to the PEG group, as evaluated by both the patients and endoscopist.
PEG was associated with an increased incidence of nausea.
There were no statistical differences between the groups in terms of vomiting, abdominal pain or fullness, dizziness, unfavorable palatability, dry mouth, palpitation, tinnitus, and tongue numbness.
Conclusion.
A single 2 L dose of a lactulose oral solution had higher efficacy, improved tolerability, and acceptable safety for bowel preparation when compared to the same volume of PEG.
Thus, a lactulose oral solution may be a potential bowel-cleansing option for colonoscopy preparation.
American Psychological Association (APA)
Li, Chun-Xia& Guo, Yan& Zhu, Yang-Jie& Zhu, Jian-Ru& Xiao, Qiansong& Chen, Dongfeng…[et al.]. 2019. Comparison of Polyethylene Glycol versus Lactulose Oral Solution for Bowel Preparation prior to Colonoscopy. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1154931
Modern Language Association (MLA)
Li, Chun-Xia…[et al.]. Comparison of Polyethylene Glycol versus Lactulose Oral Solution for Bowel Preparation prior to Colonoscopy. Gastroenterology Research and Practice No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1154931
American Medical Association (AMA)
Li, Chun-Xia& Guo, Yan& Zhu, Yang-Jie& Zhu, Jian-Ru& Xiao, Qiansong& Chen, Dongfeng…[et al.]. Comparison of Polyethylene Glycol versus Lactulose Oral Solution for Bowel Preparation prior to Colonoscopy. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1154931
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154931