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Psychotropic Effects of an Alcoholic Extract from the Leaves of Albizia zygia (Leguminosae-Mimosoideae)
Joint Authors
Adjei, Samuel
Amoateng, Patrick
Osei-Safo, Dorcas
Kukuia, Kennedy Kwami Edem
Akure, Obed Awintuma
Agbemelo-Tsomafo, Constance
Adu-Poku, Shirley Nyarko
Agyeman-Badu, Kenneth Yaw
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Albizia zygia is used in Ghanaian traditional medicine for the management of mental disorders.
The present study tested the hypothesis that an extract of the leaves of Albizia zygia (AZE) may possess antipsychotic and antidepressant properties.
Method.
The novelty- and apomorphine-induced locomotor and rearing behaviours of AZE in mice were explored in an open-field observational test system.
The effects of AZE in apomorphine-induced cage climbing test, extract-induced catalepsy, and haloperidol-induced catalepsy on mice were also investigated.
Lastly, the forced swimming and tail suspension tests in mice were employed to screen the possible antidepressant effects of AZE.
Results.
AZE (100–3000 mg/kg) showed signs of central nervous system (CNS) depression under observation, with no lethality, 24 h after treatment in mice.
AZE (100–1000 mg/kg) produced a significant decrease in the frequency of novelty- and apomorphine-induced locomotor activities in mice.
The extract also significantly decreased the frequency and duration of apomorphine-induced climbing activities in mice.
AZE, while failing to produce any cataleptic event in naïve mice, significantly enhanced haloperidol-induced catalepsy at a dose of 1000 mg/kg.
However, AZE did not produce any significant antidepressant effects in the test models employed.
Conclusion.
The extract of Albizia zygia exhibited an antipsychotic-like activity in mice.
American Psychological Association (APA)
Amoateng, Patrick& Osei-Safo, Dorcas& Kukuia, Kennedy Kwami Edem& Adjei, Samuel& Akure, Obed Awintuma& Agbemelo-Tsomafo, Constance…[et al.]. 2017. Psychotropic Effects of an Alcoholic Extract from the Leaves of Albizia zygia (Leguminosae-Mimosoideae). Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154970
Modern Language Association (MLA)
Amoateng, Patrick…[et al.]. Psychotropic Effects of an Alcoholic Extract from the Leaves of Albizia zygia (Leguminosae-Mimosoideae). Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1154970
American Medical Association (AMA)
Amoateng, Patrick& Osei-Safo, Dorcas& Kukuia, Kennedy Kwami Edem& Adjei, Samuel& Akure, Obed Awintuma& Agbemelo-Tsomafo, Constance…[et al.]. Psychotropic Effects of an Alcoholic Extract from the Leaves of Albizia zygia (Leguminosae-Mimosoideae). Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154970
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154970