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The Effects of Curcumin on Wound Healing in a Rat Model of Nasal Mucosal Trauma
Joint Authors
Kalkan, Yildiray
Tümkaya, Levent
Emiroglu, Gokhan
Ozergin Coskun, Zerrin
Celebi Erdivanli, Ozlem
Terzi, Suat
Özgür, Abdulkadir
Demirci, Munir
Dursun, Engin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We explored the effects of topical curcumin on the healing of nasal mucosal wounds.
A total of 32 Sprague-Dawley Albino rats were randomized in equal numbers into four groups, and unilateral nasal wounds were created using an interdental brush.
Group 1 (the sham-control group) contained untreated rats with traumatized right-side nasal cavities; Group 2 and 3 rats were similarly traumatized and treated with topical curcumin (5 and 10 mg/mL) dissolved in dimethyl sulfoxide daily for 7 days after trauma; Group 4 rats were treated with topical dimethyl sulfoxide only.
All rats were decapitated on day 15 and the healing sites evaluated by blinded observers in terms of the presence of cellular hyperplasia, goblet cell hypertrophy and degeneration, leucocytic infiltration, ciliary loss and degeneration, edema, and vascular dilation.
On histopathological evaluation, all of cellular hyperplasia, leukocytic infiltration, and edema were significantly reduced in Group 3 compared with Group 1 (p=0.001, p=0.004, and p=0.008, resp.).
Thus, curcumin reduced the inflammatory response and significantly accelerated wound healing.
American Psychological Association (APA)
Emiroglu, Gokhan& Ozergin Coskun, Zerrin& Kalkan, Yildiray& Celebi Erdivanli, Ozlem& Tümkaya, Levent& Terzi, Suat…[et al.]. 2017. The Effects of Curcumin on Wound Healing in a Rat Model of Nasal Mucosal Trauma. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1155006
Modern Language Association (MLA)
Emiroglu, Gokhan…[et al.]. The Effects of Curcumin on Wound Healing in a Rat Model of Nasal Mucosal Trauma. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1155006
American Medical Association (AMA)
Emiroglu, Gokhan& Ozergin Coskun, Zerrin& Kalkan, Yildiray& Celebi Erdivanli, Ozlem& Tümkaya, Levent& Terzi, Suat…[et al.]. The Effects of Curcumin on Wound Healing in a Rat Model of Nasal Mucosal Trauma. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1155006
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155006