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Safety of Simultaneous Hepatectomy and Splenectomy in the Treatment of Hepatocellular Carcinoma Complicated with Hypersplenism: A Meta-analysis
Joint Authors
Liu, Xuefeng
Chen, Zhiqiang
Yu, Meng
Zhou, Wei
Zhi, Xuting
Li, Tao
Source
Gastroenterology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-14
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Background.
We conducted this meta-analysis to compare the efficacy and safety of simultaneous hepatectomy and splenectomy (HS) with hepatectomy alone (HA) in patients with hepatocellular carcinoma (HCC) and hypersplenism.
Materials and Methods.
A systematic search was conducted in PubMed, Embase, Cochrane Library, and Wanfang Data through March 1, 2018, with no limits.
Two investigators independently screened all retrieved studies.
The investigators of the original publications were contacted if required information was absent.
All the included studies were managed by EndNote X7.
Quality assessment of the included studies was performed using a modified Newcastle-Ottawa Scale judgment.
Extracted data for each endpoint were analyzed by using STATA 12.0 software.
Results.
Thirteen studies, including a total of 1468 patients, comparing the effects of HS with HA were pooled in this meta-analysis.
Outcomes including postoperative complications, perioperative mortality, intraoperative blood transfusion, and albumin (ALB) content at postoperation day (POD) 7 did not differ significantly between the two groups.
Simultaneous approaches significantly promoted 1-, 3-, and 5-year disease-free survival (DFS) rates and overall survival (OS) rates, prolonged operation time, aggravated intraoperative blood loss, increased white blood cell (WBC) and platelet (PLT) counts at POD 7, and lowered total bilirubin (T-Bil) contents at POD 1 and 7.
Conclusion.
Compared to HA, HS is safer and more effective in ameliorating liver function and improving survival of HCC patients complicated with hypersplenism.
This trial is registered with CRD42018093779.
American Psychological Association (APA)
Liu, Xuefeng& Chen, Zhiqiang& Yu, Meng& Zhou, Wei& Zhi, Xuting& Li, Tao. 2019. Safety of Simultaneous Hepatectomy and Splenectomy in the Treatment of Hepatocellular Carcinoma Complicated with Hypersplenism: A Meta-analysis. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1155549
Modern Language Association (MLA)
Liu, Xuefeng…[et al.]. Safety of Simultaneous Hepatectomy and Splenectomy in the Treatment of Hepatocellular Carcinoma Complicated with Hypersplenism: A Meta-analysis. Gastroenterology Research and Practice No. 2019 (2019), pp.1-17.
https://search.emarefa.net/detail/BIM-1155549
American Medical Association (AMA)
Liu, Xuefeng& Chen, Zhiqiang& Yu, Meng& Zhou, Wei& Zhi, Xuting& Li, Tao. Safety of Simultaneous Hepatectomy and Splenectomy in the Treatment of Hepatocellular Carcinoma Complicated with Hypersplenism: A Meta-analysis. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1155549
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155549