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Investigation into the Individualized Treatment of Traditional Chinese Medicine through a Series of N-of-1 Trials
Joint Authors
Zhang, Yuqing
Huang, Haiyin
Ma, Ying
Wu, Yingen
Wang, Zhenwei
Yang, Peilan
Wang, Jie
Zi, Suna
Tang, Jie
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Purpose.
To compare the efficacy of individualized herbal decoction with standard decoction for patients with stable bronchiectasis through N-of-1 trials.
Methods.
We conducted a single center N-of-1 trials in 17 patients with stable bronchiectasis.
Each N-of-1 trial contains three cycles.
Each cycle is divided into two 4-week intervention including individualized decoction and fixed decoction (control).
The primary outcome was patient self-reported symptoms scores on a 1–7 point Likert scale.
Secondary outcomes were 24-hour sputum volume and CAT scores.
Results.
Among 14 completed trials, five showed that the individualized decoction was statistically better than the control decoction on symptom scores (P<0.05) but was not clinically significant.
The group data of all the trials showed that individualized decoction was superior to control decoction on symptom scores (2.13±0.58 versus 2.30±0.65, P=0.002, mean difference and 95% CI: 0.18 (0.10, 0.25)), 24 h sputum volume (P=0.009), and CAT scores (9.69±4.89 versus 11.64±5.59, P=0.013, mean difference and 95% CI: 1.95 (1.04, 2.86)) but not clinically significant.
Conclusion.
Optimizing the combined analysis of individual and group data and the improvement of statistical models may make contribution in establishing a method of evaluating clinical efficacy in line with the characteristics of traditional Chinese medicine individual diagnosis and treatment.
American Psychological Association (APA)
Huang, Haiyin& Yang, Peilan& Wang, Jie& Wu, Yingen& Zi, Suna& Tang, Jie…[et al.]. 2018. Investigation into the Individualized Treatment of Traditional Chinese Medicine through a Series of N-of-1 Trials. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1155633
Modern Language Association (MLA)
Huang, Haiyin…[et al.]. Investigation into the Individualized Treatment of Traditional Chinese Medicine through a Series of N-of-1 Trials. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1155633
American Medical Association (AMA)
Huang, Haiyin& Yang, Peilan& Wang, Jie& Wu, Yingen& Zi, Suna& Tang, Jie…[et al.]. Investigation into the Individualized Treatment of Traditional Chinese Medicine through a Series of N-of-1 Trials. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1155633
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155633