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Efficacy and Safety of Aidi Injection Combined with Transcatheter Arterial Chemoembolization on Primary Hepatic Carcinoma: A Systematic Review and Meta-Analysis
Joint Authors
Xiao, Ya
Chen, Ruixue
Chen, Weihao
Chen, Liguo
Chen, Xudong
Liang, Qiuer
Cai, Yunfei
Wang, Yurong
Zhang, Yun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-24
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Objectives.
To evaluate the efficacy and safety of Aidi injection (ADI) combined with transcatheter arterial chemoembolization (TACE) for primary hepatic carcinoma (PHCC).
Methods.
We conducted a literature search in EMBASE, PubMed, CENTRAL, MEDLINE, CNKI, Wanfang, and VIP databases from the earliest possible year to April 2018.
Randomized controlled trials (RCTs) involving ADI combined with TACE versus TACE alone for patients with PHCC were included.
The Cochrane Risk of Bias tool was applied for quality assessment.
Results.
22 studies involving 1611 participants were included.
The clinical response rate (RR = 1.28, 95% CI: 1.17-1.40; P < 0.00001), KPS score (RR = 1.78, 95% CI: 1.59-2.00; P < 0.00001), survival rate (RR = 1.27, 95% CI: 1.16-1.39; P < 0.00001), immune function (MD = 1.24, 95% CI: 0.98-1.51; P < 0.00001), and adverse effects (RR = 0.62, 95% CI: 0.57-0.68; P < 0.00001) of ADI plus TACE showed significant difference when compared with TACE alone.
Conclusions.
ADI combined with TACE in the treatment of PHCC improved the clinical response rate and safety compared to TACE alone.
However, due to poor methodological quality of many of the included RCTs, more rigorously designed and large-scale RCTs are warranted to examine this beneficial effect in the future.
American Psychological Association (APA)
Chen, Weihao& Wang, Yurong& Liang, Qiuer& Cai, Yunfei& Chen, Xudong& Zhang, Yun…[et al.]. 2018. Efficacy and Safety of Aidi Injection Combined with Transcatheter Arterial Chemoembolization on Primary Hepatic Carcinoma: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1155868
Modern Language Association (MLA)
Chen, Weihao…[et al.]. Efficacy and Safety of Aidi Injection Combined with Transcatheter Arterial Chemoembolization on Primary Hepatic Carcinoma: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1155868
American Medical Association (AMA)
Chen, Weihao& Wang, Yurong& Liang, Qiuer& Cai, Yunfei& Chen, Xudong& Zhang, Yun…[et al.]. Efficacy and Safety of Aidi Injection Combined with Transcatheter Arterial Chemoembolization on Primary Hepatic Carcinoma: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1155868
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155868