Exploring Chemical Basis of Toxicity Reduction for Processed Roots of Stellera chamaejasme L. Using Ultraperformance Liquid Chromatography–Triple Quadrupole Tandem Mass Spectrometry
Joint Authors
Yang, Wei
Ma, Xiaoli
Wang, Ludi
Wei, Mengmeng
Wang, Shuyao
Wu, Siyang
Kang, Chen
Li, Yingfei
Source
International Journal of Analytical Chemistry
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Some herbal medicines are treated with various processing methods to ensure their safe and effective use.
However, chemical basis of toxicity reducing for most herbal medicines remains unclear.
Stellera chamaejasme L., particularly the root (ruixianglangdu), is toxic.
Thus, ruixianglangdu is commonly processed with vinegar or milk to reduce toxicity.
Here, with help of multiple-ion monitoring (MIM)-based metabolomics, we comprehensively capture chemical information of ruixianglangdu.
Then, 33 differential components between crude drugs and processed products were identified or tentatively characterized by multiple-ion monitoring–information dependent acquiring–enhanced product ion (MIM-IDA-EPI), whose level changed after being processed by vinegar or milk.
It was found that flavonoids especially biflavonones could be the important chemical basis of toxicity reduction for processed ruixianglangdu.
In addition, some coumarins and lignanoids could also play a role in reducing toxicity.
It is believed that MIM-based metabolomics method was valuable for exploring chemical basis of toxicity reduction for processing.
The data is critical to further study the mechanism of toxicity reducing for processed ruixianglangdu.
American Psychological Association (APA)
Yang, Wei& Ma, Xiaoli& Wang, Ludi& Wei, Mengmeng& Wang, Shuyao& Wu, Siyang…[et al.]. 2019. Exploring Chemical Basis of Toxicity Reduction for Processed Roots of Stellera chamaejasme L. Using Ultraperformance Liquid Chromatography–Triple Quadrupole Tandem Mass Spectrometry. International Journal of Analytical Chemistry،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1155895
Modern Language Association (MLA)
Yang, Wei…[et al.]. Exploring Chemical Basis of Toxicity Reduction for Processed Roots of Stellera chamaejasme L. Using Ultraperformance Liquid Chromatography–Triple Quadrupole Tandem Mass Spectrometry. International Journal of Analytical Chemistry No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1155895
American Medical Association (AMA)
Yang, Wei& Ma, Xiaoli& Wang, Ludi& Wei, Mengmeng& Wang, Shuyao& Wu, Siyang…[et al.]. Exploring Chemical Basis of Toxicity Reduction for Processed Roots of Stellera chamaejasme L. Using Ultraperformance Liquid Chromatography–Triple Quadrupole Tandem Mass Spectrometry. International Journal of Analytical Chemistry. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1155895
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155895