Immunotoxicological Evaluation of Schinus molle L. (Anacardiaceae) Essential Oil in Lymphocytes and Macrophages
Joint Authors
Bolignon, Aline
Machado, Michel Mansur
Duarte, Jonathaline Apollo
Zambrano, Léa Augusta de Bairros
Quintana, Luciane Dias
Rocha, Mariana Balhego
Schmitt, Elizandra Gomes
Anraku de Campos, Marli Matiko
Oliveira, Luís Flávio Souza de
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Schinus molle L.
is used to treat various diseases; however, the literature lacks information regarding its possible immunotoxic effects.
The aim of the study was to investigate the immunotoxic effects of essential oil from leaves of Schinus molle L.
in cultures of human lymphocytes and macrophages.
The cultures were treated with essential oil (EO) of Schinus molle L.
and subsequently subjected to genotoxic analysis (comet assay), mutagenic analysis (micronucleus frequency and chromosomal aberration), and cytotoxic (cell viability) and functional parameters (interleukins secretions).
Our analyses have determined that the essential oil from leaves of Schinus molle L.
presents several compounds with α-pinene being the major compound; in addition, the compound verbenene was firstly identified; genotoxic effects were detected only in macrophages and only at the two highest concentrations tested.
An important finding is that Schinus molle L.
oil causes an activation of the immune system.
This action has its mechanism centered by the cascade nitric oxide-interleukin-10-tumor necrosis factor alpha.
American Psychological Association (APA)
Duarte, Jonathaline Apollo& Zambrano, Léa Augusta de Bairros& Quintana, Luciane Dias& Rocha, Mariana Balhego& Schmitt, Elizandra Gomes& Bolignon, Aline…[et al.]. 2018. Immunotoxicological Evaluation of Schinus molle L. (Anacardiaceae) Essential Oil in Lymphocytes and Macrophages. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155933
Modern Language Association (MLA)
Duarte, Jonathaline Apollo…[et al.]. Immunotoxicological Evaluation of Schinus molle L. (Anacardiaceae) Essential Oil in Lymphocytes and Macrophages. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1155933
American Medical Association (AMA)
Duarte, Jonathaline Apollo& Zambrano, Léa Augusta de Bairros& Quintana, Luciane Dias& Rocha, Mariana Balhego& Schmitt, Elizandra Gomes& Bolignon, Aline…[et al.]. Immunotoxicological Evaluation of Schinus molle L. (Anacardiaceae) Essential Oil in Lymphocytes and Macrophages. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155933
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155933