The Traditional Chinese Medicine Fufang Shatai Heji (STHJ) Enhances Immune Function in Cyclophosphamide-Treated Mice
Joint Authors
Fan, Kai-Jian
Li, Yun-Wu
Wu, Jing
Li, Jun
Zhang, Jun
Wang, Qi-Shan
Xu, Bing-Xin
Cai, Qing
Wang, Ting-Yu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Fufang Shatai Heji (STHJ) is a mixture of traditional Chinese medicines, such as Radix Adenophorae, Radix Pseudostellariae, and Radix Astragali.
STHJ is commonly used to treat diseases caused by low immune function, for example, Sjögren’s syndrome (SS).
The primary objective of this study was to assess the immunopotentiating effect of STHJ using an immunosuppressive mouse model receiving cyclophosphamide (CTX).
Following CTX treatment, STHJ was administered by oral gavage for 30 consecutive days.
The percentage of specific lymphocyte subpopulations in the spleen was measured by flow cytometry.
Levels of inflammatory factors in serum were detected by enzyme-linked immunosorbent assays (ELISAs).
The administration of STHJ significantly elevated thymus and spleen indices, increased B cell and natural killer (NK) cell activities, and decreased CD8+ T, CD8+CD122+ T, NKT, and γδT cell activities in the CTX-treated mice.
In addition, STHJ upregulated the expression of interleukin- (IL-) 2, IL-6, and tumor necrosis factor-α (TNF-α) and downregulated IL-10 expression in CTX-treated mice.
In conclusion, STHJ effectively remitted CTX-induced immunosuppression by modulating the balance of lymphocyte subsets and cytokines.
Our results suggest STHJ treatment could be used as an effective therapeutic approach to improve immune function in patients with low immunity.
American Psychological Association (APA)
Fan, Kai-Jian& Li, Yun-Wu& Wu, Jing& Li, Jun& Zhang, Jun& Wang, Qi-Shan…[et al.]. 2020. The Traditional Chinese Medicine Fufang Shatai Heji (STHJ) Enhances Immune Function in Cyclophosphamide-Treated Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1155964
Modern Language Association (MLA)
Fan, Kai-Jian…[et al.]. The Traditional Chinese Medicine Fufang Shatai Heji (STHJ) Enhances Immune Function in Cyclophosphamide-Treated Mice. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1155964
American Medical Association (AMA)
Fan, Kai-Jian& Li, Yun-Wu& Wu, Jing& Li, Jun& Zhang, Jun& Wang, Qi-Shan…[et al.]. The Traditional Chinese Medicine Fufang Shatai Heji (STHJ) Enhances Immune Function in Cyclophosphamide-Treated Mice. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1155964
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155964