Herbal Formula Gegen-Qinlian Decoction for Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trials
Joint Authors
Ren, Lin
Cheng, Yanxia
Qin, Feng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Herbal formula Gegen-Qinlian Decoction (GQD) has been widely used in China for the treatment of type 2 diabetes mellitus (T2DM), but its efficacy and safety are unclear.
Method.
The studies were identified from the PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure database, Wanfang database, and VIP database using the keywords “Gegenqinlian” or “Gegen-Qinlian” or “Gegen-Qin-Lian” or “Ge Gen Qin Lian.” Relevant studies were selected according to predefined inclusion and exclusion criteria.
Study selection, data extraction, and validation were carried out by, at least, two reviewers with disagreements being settled by discussion.
Results.
After literature search, a total of 26 randomized controlled trials were included with a total of 2553 patients.
There was evidence that compared with metformin, the combination of GQD and metformin significantly reduced the fasting plasma glucose levels (MD −1.79, 95% CI (−2.31, −1.27), p<0.00001); 2-hour postprandial plasma glucose levels (MD −1.72, 95% CI (−2.12, −1.31), p<0.00001); and glycosylated hemoglobin levels (MD −1.26, 95% CI (−1.80, −0.72), p<0.00001), and no serious side effects were identified.
Conclusion.
These data suggest that GQD may be an effective herbal formula in treating T2DM without serious side effects.
The addition of GQD also enhances the hypoglycemic effects of metformin.
However, the evidence remains weak due to methodological flaws, which may amplify the therapeutic benefit of GQD.
American Psychological Association (APA)
Ren, Lin& Cheng, Yanxia& Qin, Feng. 2020. Herbal Formula Gegen-Qinlian Decoction for Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1155987
Modern Language Association (MLA)
Ren, Lin…[et al.]. Herbal Formula Gegen-Qinlian Decoction for Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1155987
American Medical Association (AMA)
Ren, Lin& Cheng, Yanxia& Qin, Feng. Herbal Formula Gegen-Qinlian Decoction for Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1155987
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155987