In Vivo Antiplasmodial Activity of Two Sahelian Plant Extracts on Plasmodium berghei ANKA Infected NMRI Mice
Joint Authors
Bonkian, Léa Nadège
Yerbanga, R. Serge
Koama, Benjamin
Soma, Aboubakar
Cisse, Mamoudou
Valea, Innocent
Tinto, Halidou
Ouedraogo, Jean Bosco
Guigemde, T. Robert
Traore/Coulibaly, Maminata
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-24
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Up to now, the control of malaria remains a challenge.
The World Health Organization (WHO) recommends the use of artemisinin-based combination therapies (ACTs) for uncomplicated malaria treatment.
Despite this guideline, many people in Burkina Faso use herbal medicine as primary treatment against malaria.
The aim of this study was to assess the in vivo activity of Guiera senegalensis J.
F.
Gmel and Bauhinia rufescens Lam.
leaves extracts against Plasmodium berghei ANKA.
A four-day treatment of leaves decoction of each plant was administrated orally to 7 groups of six NMRI (Naval Medical Research Institute) mice infected with Plasmodium berghei ANKA strain.
The control group received distilled water as treatment while the treated groups each received daily 100, 250, and 500 mg extract/kg body weight.
Thin blood smears were performed on day five and the percentage of reduction of parasitaemia was determined compared to the control.
The percentages of reduction of the parasitaemia at the doses of 100, 250, and 500 mg extract/kg body weight were, respectively, 57.5%, 35.9%, and 44.9% for Guiera senegalensis and 50.6%, 22.2%, and 25.7% for Bauhinia rufescens.
Our findings on antiplasmodial activity of these two plants justify the traditional use by local populations against malaria.
Thus, the isolation of the active compounds from these two plants is suggested for possible antimalarial candidate drugs.
American Psychological Association (APA)
Bonkian, Léa Nadège& Yerbanga, R. Serge& Koama, Benjamin& Soma, Aboubakar& Cisse, Mamoudou& Valea, Innocent…[et al.]. 2018. In Vivo Antiplasmodial Activity of Two Sahelian Plant Extracts on Plasmodium berghei ANKA Infected NMRI Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1156056
Modern Language Association (MLA)
Bonkian, Léa Nadège…[et al.]. In Vivo Antiplasmodial Activity of Two Sahelian Plant Extracts on Plasmodium berghei ANKA Infected NMRI Mice. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1156056
American Medical Association (AMA)
Bonkian, Léa Nadège& Yerbanga, R. Serge& Koama, Benjamin& Soma, Aboubakar& Cisse, Mamoudou& Valea, Innocent…[et al.]. In Vivo Antiplasmodial Activity of Two Sahelian Plant Extracts on Plasmodium berghei ANKA Infected NMRI Mice. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1156056
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156056