Effects of a Long-Acting Formulation of Octreotide on Patients with Portal Hypertension
Joint Authors
Cui, Pei-Jing
Yao, Jing
Zhu, Yin
Zhang, Zheng-Yun
Yang, Jun
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
This study aimed to determine whether the treatment of a long-acting formulation of octreotide (OCT-LAR) exerted a similar effect on improving the prognosis of patients with portal hypertension compared with placement of transjugular intrahepatic portosystemic shunts (TIPSs).
Methods.
A total of 24 patients with portal hypertension who underwent TIPS placement or OCT-LAR treatment from January 2010 to January 2015 were reviewed.
Hemodynamic studies, biological values, live functions, and treatment complications before and during the treatment were evaluated.
Results.
Baseline clinical characteristics were similar between two groups.
Hepatic venous pressure gradient (HVPG) was improved in OCT-LAR groups (15.9 ± 2.4 to 12.8 ± 1.6 mmHg).
Both groups showed a slight decrease in endothelin-1 (ET-1) and urotensin II and a slight increase in oxide metabolite (NOx) concentrations with no significant difference.
Aspartate aminotransferase and alanine aminotransferase increased one week after TIPS placement when they improved in the OCT-LAR treatment group.
The complications of OCT-LAR treatment were minor and transient.
However, one patient who received TIPS placement presented procedure-related complications and required rehospitalization, and 2 patients had developed hepatic encephalopathy during the follow-up period.
Conclusion.
Prolonged administration of OCT-LAR exerted a virtually similar effect on improving hemodynamic parameters and liver function in patients with portal hypertension compared with placement of TIPS, with no apparent serious adverse effects.
American Psychological Association (APA)
Cui, Pei-Jing& Yao, Jing& Zhu, Yin& Zhang, Zheng-Yun& Yang, Jun. 2017. Effects of a Long-Acting Formulation of Octreotide on Patients with Portal Hypertension. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1156362
Modern Language Association (MLA)
Cui, Pei-Jing…[et al.]. Effects of a Long-Acting Formulation of Octreotide on Patients with Portal Hypertension. Gastroenterology Research and Practice No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1156362
American Medical Association (AMA)
Cui, Pei-Jing& Yao, Jing& Zhu, Yin& Zhang, Zheng-Yun& Yang, Jun. Effects of a Long-Acting Formulation of Octreotide on Patients with Portal Hypertension. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1156362
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156362