Clinicopathological Features and Prognostic Factors of Colorectal Neuroendocrine Neoplasms
Joint Authors
Jiang, Mengjie
Tan, Yinuo
Li, Xiaofen
Fu, Jianfei
Hu, Hanguang
Ye, Xianyun
Cao, Ying
Xu, Jinghong
Yuan, Ying
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Limited research is available regarding colorectal NENs and the prognostic factors remain controversial.
Materials and Methods.
A total of 68 patients with colorectal NENs were studied retrospectively.
Clinical characteristics and prognosis between colonic and rectal NENs were compared.
The Cox regression models were used to evaluate the predictive capacity.
Results.
Of the 68 colorectal NENs patients, 43 (63.2%) had rectal NENs, and 25 (36.8%) had colonic NENs.
Compared with rectal NENs, colonic NENs more frequently exhibited larger tumor size (P<0.0001) and distant metastasis (P<0.0001).
Colonic NENs had a worse prognosis (P=0.027), with 5-year overall survival rates of 66.7% versus 88.1%.
NET, NEC, and MANEC were noted in 61.8%, 23.5%, and 14.7% of patients, respectively.
Multivariate analyses revealed that tumor location was not an independent prognostic factor (P=0.081), but tumor size (P=0.037) and pathological classification (P=0.012) were independent prognostic factors.
Conclusion.
Significant differences exist between colonic and rectal NENs.
Multivariate analysis indicated that tumor size and pathological classification were associated with prognosis.
Tumor location was not an independent factor.
The worse outcome of colonic NENs observed in clinical practice might be due not only to the biological differences, but also to larger tumor size in colonic NENs caused by the delayed diagnosis.
American Psychological Association (APA)
Jiang, Mengjie& Tan, Yinuo& Li, Xiaofen& Fu, Jianfei& Hu, Hanguang& Ye, Xianyun…[et al.]. 2017. Clinicopathological Features and Prognostic Factors of Colorectal Neuroendocrine Neoplasms. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1156376
Modern Language Association (MLA)
Jiang, Mengjie…[et al.]. Clinicopathological Features and Prognostic Factors of Colorectal Neuroendocrine Neoplasms. Gastroenterology Research and Practice No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1156376
American Medical Association (AMA)
Jiang, Mengjie& Tan, Yinuo& Li, Xiaofen& Fu, Jianfei& Hu, Hanguang& Ye, Xianyun…[et al.]. Clinicopathological Features and Prognostic Factors of Colorectal Neuroendocrine Neoplasms. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1156376
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156376