Clostridium difficile in Inflammatory Bowel Disease: A Retrospective Study
Joint Authors
Gillespie, William
Marya, Neil
Fahed, Julien
Leslie, Gregory
Patel, Krunal
Cave, David R.
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-04
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aim.
To investigate the epidemiology and risk factors of Clostridium difficile infections (CDI) in patients with inflammatory bowel disease (IBD).
Methods.
This is a retrospective study of patients diagnosed with IBD.
1006 charts were screened and 654 patients met the inclusion criteria.
Patients were divided into 2 cohorts based on the presence of prior diagnosis of CDI.
Statistical analysis with Pearson’s chi-squared and two-sample t-test was performed.
Results.
The incidence of CDI among IBD patients was 6.7%.
There was equal prevalence of CDI among Crohn’s disease (CD) (n=21, 49%) and ulcerative colitis (UC) (n=22, 51%).
IBD patients acquired CDI at a mean age of 42.7 years, with 56% of infections acquired in the community and only 28% associated with healthcare.
Only 30% of IBD patients with CDI had prior antibiotic use, and 16% had prior steroid use.
IBD patients were significantly more likely to require biologic therapy (57% versus 37%, p<0.01) and have extraintestinal manifestations of IBD (43% versus 28%, p<0.02).
Conclusions.
IBD patients are more susceptible to CDI at a younger age and often lack traditional risk factors.
IBD patients with at least one CDI were more likely to require biologic therapy and had greater rates of extraintestinal manifestations.
American Psychological Association (APA)
Gillespie, William& Marya, Neil& Fahed, Julien& Leslie, Gregory& Patel, Krunal& Cave, David R.. 2017. Clostridium difficile in Inflammatory Bowel Disease: A Retrospective Study. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1156411
Modern Language Association (MLA)
Gillespie, William…[et al.]. Clostridium difficile in Inflammatory Bowel Disease: A Retrospective Study. Gastroenterology Research and Practice No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1156411
American Medical Association (AMA)
Gillespie, William& Marya, Neil& Fahed, Julien& Leslie, Gregory& Patel, Krunal& Cave, David R.. Clostridium difficile in Inflammatory Bowel Disease: A Retrospective Study. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1156411
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156411