Antibacterial Effects of Leaf Extract of Nandina domestica and the Underlined Mechanism
Joint Authors
Guo, Zhao-Yu
Zhang, Zhuo-Yang
Xiao, Jia-Qi
Qin, Jin-Hong
Zhao, Wei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aim.
The study was conducted to investigate the antibacterial and antiasthmatic effects of Nandina domestica leaf extract, to find out its active components, and to assess its safety issue.
Methods.
(1) Solid-phase agar dilution method was used for antibacterial activity test of nandina leaf extract and the change of bacterial morphology after treatment was observed under the transmission microscope; (2) guinea pig model of asthma was used to test the asthma prevention effect of nandina leaf extract; (3) alkaloids and flavones were separated from nandina leaf extract and were further analyzed with HPLC-MS; (4) mice model was used to assessment of the safety issue of nandina leaf extract.
Results.
(1) Nandina leaf extract inhibited the growth of bacteria and destroyed bacterial membrane; (2) nandina leaf extract alleviated animal allergy and asthma; (3) the components reextracted by ethyl acetate were active, in which alkaloids inhibited Gram-positive bacteria and prevented asthma and flavones inhibited Gram-negative bacteria; (4) nandina leaf extract had no toxic effect on mice.
Conclusion.
Nandina leaves inhibit bacterial growth and prevent asthma through alkaloids and flavones, which had integrated function against chronic bronchitis.
This study provided theoretical basement for producing new Chinese medicine against chronic bronchitis.
American Psychological Association (APA)
Guo, Zhao-Yu& Zhang, Zhuo-Yang& Xiao, Jia-Qi& Qin, Jin-Hong& Zhao, Wei. 2018. Antibacterial Effects of Leaf Extract of Nandina domestica and the Underlined Mechanism. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156498
Modern Language Association (MLA)
Guo, Zhao-Yu…[et al.]. Antibacterial Effects of Leaf Extract of Nandina domestica and the Underlined Mechanism. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1156498
American Medical Association (AMA)
Guo, Zhao-Yu& Zhang, Zhuo-Yang& Xiao, Jia-Qi& Qin, Jin-Hong& Zhao, Wei. Antibacterial Effects of Leaf Extract of Nandina domestica and the Underlined Mechanism. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156498
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156498