Simultaneous Determination of Columbianadin and Its Metabolite Columbianetin in Rat Plasma by LC-MSMS: Application to Pharmacokinetics of Columbianadin after Oral Administration
Joint Authors
Chang, Yanxu
Li, Jin
He, Jun
Teye Azietaku, John
Luo, Qian
Wang, Chun-peng
Li, Zhen
Pang, Xiaoli
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Columbianadin and its metabolite columbianetin exhibited the anti-inflammatory, analgesic, calcium channel blocking and antitumor activities.
To compare the differences between pharmacokinetics of columbianadin and its metabolite columbianetin after oral administration of pure columbianadin and Angelicae Pubescentis Radix (APR) extract, a simple and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was established and validated to simultaneously determine columbianadin and columbianetin in rat plasma.
Two analytes and an internal standard (warfarin) were well separated and determined after liquid-liquid extraction with ethyl acetate.
Ammonium acetate aqueous solution (1 mmol/L) and acetonitrile were used as the mobile phase and the flow rate was 0.3 mL/min.
The lower limit of quantification (LLOQ) was 0.1 ng/mL for columbianetin and 0.5 ng/mL for columbianadin, respectively.
There were significant differences between some pharmacokinetic parameters and bioavailability of columbianadin after oral administration of pure columbianadin and APR extract.
The studies on comparative pharmacokinetics of columbianadin were of great use for facilitating the clinical application of columbianadin and were also highly meaningful for the potential development of APR.
American Psychological Association (APA)
Li, Jin& Li, Zhen& Luo, Qian& Wang, Chun-peng& He, Jun& Pang, Xiaoli…[et al.]. 2018. Simultaneous Determination of Columbianadin and Its Metabolite Columbianetin in Rat Plasma by LC-MSMS: Application to Pharmacokinetics of Columbianadin after Oral Administration. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156623
Modern Language Association (MLA)
Li, Jin…[et al.]. Simultaneous Determination of Columbianadin and Its Metabolite Columbianetin in Rat Plasma by LC-MSMS: Application to Pharmacokinetics of Columbianadin after Oral Administration. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1156623
American Medical Association (AMA)
Li, Jin& Li, Zhen& Luo, Qian& Wang, Chun-peng& He, Jun& Pang, Xiaoli…[et al.]. Simultaneous Determination of Columbianadin and Its Metabolite Columbianetin in Rat Plasma by LC-MSMS: Application to Pharmacokinetics of Columbianadin after Oral Administration. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156623
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156623