Prevalence of Anemia in Pediatric IBD Patients and Impact on Disease Severity: Results of the Pediatric IBD-Registry CEDATA-GPGE®
Joint Authors
Laffolie, Jan de
Laass, Martin W.
Scholz, Dietmar
Zimmer, Klaus-Peter
Buderus, Stephan
M'Koma, Amosy
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
To determine the prevalence of anemia and its association with disease severity in children and adolescents with IBD.
Methods.
CEDATA-GPGE is a registry for pediatric patients with IBD in Germany and Austria from 90 specialized centers.
As markers of disease severity, analysis included patient self-assessment on a Likert scale (1–5; 1 = very good) and physicians’ general assessment (0 = no activity to 4 = severe disease) and the disease indices.
Anemia was defined as hemoglobin concentration below the 3rd percentile.
Results.
Prevalence of anemia was 65.2% in CD and 60.2% in UC.
Anemic CD and UC patients showed significantly worse self-assessment than patients without anemia (average ± standard deviation; CD: 3.0 ± 0.9 versus 2.5 ± 0.9, p<0.0001; UC: 2.9 ± 0.9 versus 2.3 ± 0.9, p<0.0001).
Accordingly, physicians’ general assessment (PGA) was significantly worse in anemic than in nonanemic patients in CD (p<0.0001) and UC (p<0.0001).
PCDAI in anemic CD, p<0.0001, and PUCAI in anemic UC patients, p<0.0001, were significantly higher than in nonanemic patients.
40.0% of anemic CD and 47.8% of anemic UC patients received iron during follow-up.
Conclusion.
Almost 2/3 of pediatric IBD patients are anemic.
Patients’ self-assessment and disease severity as determined by PGA and activity indices are worse in anemic patients.
Contrastingly, only a minority received iron therapy.
American Psychological Association (APA)
Laffolie, Jan de& Laass, Martin W.& Scholz, Dietmar& Zimmer, Klaus-Peter& Buderus, Stephan& M'Koma, Amosy. 2017. Prevalence of Anemia in Pediatric IBD Patients and Impact on Disease Severity: Results of the Pediatric IBD-Registry CEDATA-GPGE®. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1156669
Modern Language Association (MLA)
Laffolie, Jan de…[et al.]. Prevalence of Anemia in Pediatric IBD Patients and Impact on Disease Severity: Results of the Pediatric IBD-Registry CEDATA-GPGE®. Gastroenterology Research and Practice No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1156669
American Medical Association (AMA)
Laffolie, Jan de& Laass, Martin W.& Scholz, Dietmar& Zimmer, Klaus-Peter& Buderus, Stephan& M'Koma, Amosy. Prevalence of Anemia in Pediatric IBD Patients and Impact on Disease Severity: Results of the Pediatric IBD-Registry CEDATA-GPGE®. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1156669
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156669