Network Pharmacology-Based Identification of the Mechanisms of Shen-Qi Compound Formula in Treating Diabetes Mellitus
Joint Authors
Liu, Ya
Yang, Liangjun
Hu, Zhipeng
Yang, Maoyi
Xie, Chunguang
Gao, Hong
Fu, Xiaoxu
Xie, Hongyan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-04
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Aim.
The purpose of this research is to identify the mechanisms of Shen-Qi compound formula (SQC), a traditional Chinese medicine (TCM), for treating diabetes mellitus (DM) using system pharmacology.
Methods.
The active components and therapeutic targets were identified, and these targets were analyzed using gene ontology (GO) enrichment analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, and protein-protein interaction (PPI) analysis.
Finally, an integrated pathway was constructed to show the mechanisms of SQC.
Results.
A total of 282 active components and 195 targets were identified through a database search.
The component-target network was constructed, and the key components were screened out according to their degree.
Through the GO, PPI, and KEGG analyses, the mechanism network of SQC treating DM was constructed.
Conclusions.
This study shows that the mechanisms of SQC treating DM are related to various pathways and targets.
This study provides a good foundation and basis for further in-depth verification and clinical application.
American Psychological Association (APA)
Hu, Zhipeng& Yang, Maoyi& Yang, Liangjun& Xie, Chunguang& Gao, Hong& Fu, Xiaoxu…[et al.]. 2020. Network Pharmacology-Based Identification of the Mechanisms of Shen-Qi Compound Formula in Treating Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1156711
Modern Language Association (MLA)
Hu, Zhipeng…[et al.]. Network Pharmacology-Based Identification of the Mechanisms of Shen-Qi Compound Formula in Treating Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1156711
American Medical Association (AMA)
Hu, Zhipeng& Yang, Maoyi& Yang, Liangjun& Xie, Chunguang& Gao, Hong& Fu, Xiaoxu…[et al.]. Network Pharmacology-Based Identification of the Mechanisms of Shen-Qi Compound Formula in Treating Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1156711
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156711