Efficacy and Safety of Bushenjiangya-Optimized Granule for Left Ventricular Diastolic Dysfunction in Hypertensive Patients: A Double-Blind, Randomized, Placebo-Controlled Trial
Joint Authors
Cui, Xiaoyun
Gao, Qun
Liu, Jing
Lin, Qian
Lu, Jinjin
Zhou, Kun
Qu, Wenbai
Dong, Fei
Fan, Wen-ying
Li, Pin-hui
Meng, Yan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
The study aimed to evaluate the efficacy and safety of Bushenjiangya-optimized (BSJYO) granule on left ventricular diastolic dysfunction (LVDD) in hypertensive (HTN) patients.
Methods.
120 patients diagnosed with HTN plus LVDD were randomly assigned to the BSJYO granule group and placebo group, and all patients received basal western medicine (WM) treatment.
After eight weeks of treatment, we evaluated echocardiography, traditional Chinese medicine (TCM) syndromes, 24-hour ambulatory blood pressure, liver and kidney functions, and adverse events.
Major adverse cardiovascular events (MACEs) were collected at 6-month follow-up.
Results.
Compared with pretreatment, E/Ea (Doppler-derived index of filling pressure and worsening LVDD) significantly decreased significantly after 8 weeks of treatment in the BSJYO granule plus basal WM group (10.52 ± 1.87 vs.
9.49 ± 1.49, P<0.01), alongside reductions in significantly effective response (SER), effective response (ER), and total effective response (TER = SER + ER) in TCM symptom scores (21.59% vs.
71.70%, P<0.01).
There were no differences between treatment groups in kidney and liver function, early adverse events, or MACE.
Conclusion.
BSJYO granule plus basal WM is an effective and safe therapy for HTN patients with LVDD.
American Psychological Association (APA)
Gao, Qun& Cui, Xiaoyun& Dong, Fei& Fan, Wen-ying& Li, Pin-hui& Liu, Jing…[et al.]. 2020. Efficacy and Safety of Bushenjiangya-Optimized Granule for Left Ventricular Diastolic Dysfunction in Hypertensive Patients: A Double-Blind, Randomized, Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1157186
Modern Language Association (MLA)
Gao, Qun…[et al.]. Efficacy and Safety of Bushenjiangya-Optimized Granule for Left Ventricular Diastolic Dysfunction in Hypertensive Patients: A Double-Blind, Randomized, Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1157186
American Medical Association (AMA)
Gao, Qun& Cui, Xiaoyun& Dong, Fei& Fan, Wen-ying& Li, Pin-hui& Liu, Jing…[et al.]. Efficacy and Safety of Bushenjiangya-Optimized Granule for Left Ventricular Diastolic Dysfunction in Hypertensive Patients: A Double-Blind, Randomized, Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1157186
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157186