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Evidence of TCM Theory in Treating the Same Disease with Different Methods: Treatment of Pneumonia with Ephedra sinica and Scutellariae Radix as an Example
Joint Authors
Wang, Dandan
Xu, Yan
Sun, Liping
Qi, Wenxiu
Wang, Yanbo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-28
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
Pneumonia is a serious global health problem and the leading cause of mortality in children.
Antibiotics are the main treatment for bacterial pneumonia, but there are serious drug resistance problems.
Traditional Chinese medicine (TCM) has been used to treat diseases for thousands of years and has a unique theory.
This article takes the treatment of pneumonia with Ephedra sinica as a representative hot medicine and Scutellariae Radix as a representative cold medicine as an example.
We explore and explain the theory of treating the same disease with different TCM treatments.
Using transcriptomics and network pharmacology methods, GO, KEGG enrichment, and PPI network construction were carried out, demonstrating that Ephedra sinica plays a therapeutic role through the NF-κB and apoptosis signaling pathways targeting PLAU, CD40LG, BLC2L1, CASP7, and CXCL8.
The targets of Scutellariae Radix through the IL-17 signaling pathway are MMP9, CXCL8, and MAPK14.
Molecular docking technology was also used to verify the results.
In short, our results provide evidence for the theory of treating the same disease with different treatments, and we also discuss future directions for traditional Chinese medicine.
American Psychological Association (APA)
Sun, Liping& Wang, Dandan& Xu, Yan& Qi, Wenxiu& Wang, Yanbo. 2020. Evidence of TCM Theory in Treating the Same Disease with Different Methods: Treatment of Pneumonia with Ephedra sinica and Scutellariae Radix as an Example. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-23.
https://search.emarefa.net/detail/BIM-1158157
Modern Language Association (MLA)
Sun, Liping…[et al.]. Evidence of TCM Theory in Treating the Same Disease with Different Methods: Treatment of Pneumonia with Ephedra sinica and Scutellariae Radix as an Example. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-23.
https://search.emarefa.net/detail/BIM-1158157
American Medical Association (AMA)
Sun, Liping& Wang, Dandan& Xu, Yan& Qi, Wenxiu& Wang, Yanbo. Evidence of TCM Theory in Treating the Same Disease with Different Methods: Treatment of Pneumonia with Ephedra sinica and Scutellariae Radix as an Example. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-23.
https://search.emarefa.net/detail/BIM-1158157
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158157