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In Vitro Antioxidant and Antidiabetic Potentials of Syzygium caryophyllatum L. Alston
Joint Authors
Wathsara, Herath Pathiranage Thathmi
Weeratunge, Hasitha Dhananjaya
Mubarak, Mohamed Naeem Ahammadu
Godakumbura, Pahan Indika
Ranasinghe, Pathmasiri
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-28
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Syzygium caryophyllatum L.
Alston (Family: Myrtaceae, Sinhala: Heendan) is a red-listed plant that has been used in traditional medicine in Sri Lanka for the treatment of diabetes, but it is yet to be exploited for its potential uses as a functional food or a source of supplements.
The present study focused on the evaluation of antidiabetic property of S.
caryophyllatum fruits and leaves assessing antioxidant, antiglycation, and antiamylase activities and functional mineral element composition.
The crude extracts (CR) of leaves and fruits were fractionated into hexane (Hex) ethyl acetate (EA) and aqueous (AQ) and evaluated for bioactivities along with the crude extracts.
The isolated fraction (C3) of Hex fraction of fruit showed significantly high (p<0.05) antiamylase activity with IC50 value 2.27 ± 1.81 μg/mL where the Hex fraction of fruits exhibited the IC50 value as 47.20 ± 0.3 μg/mL which was higher than acarbose (IC50: 87.96 ± 1.43 μg/mL).
The EA fraction of leaves showed highest values for DPPH radical scavenging activity, ferric reducing antioxidant power, and oxygen radical absorbance capacity.
Significantly high (p<0.05) ABTS radical scavenging activity and iron chelating activity were observed in Hex fraction of fruit.
The composition of volatiles in leaf oil was studied with GC-MS, and 58 compounds were identified.
Inductively coupled plasma-mass spectrometry data revealed the presence of biologically significant trace elements such as Fe, Zn, Mg, Cu, Se, and Sr in leaves and fruits.
It is concluded that the Hex fraction of S.
caryophyllatum fruits will be a good source for the formulation of supplements for diabetic management with further evaluation of potency and efficacy.
American Psychological Association (APA)
Wathsara, Herath Pathiranage Thathmi& Weeratunge, Hasitha Dhananjaya& Mubarak, Mohamed Naeem Ahammadu& Godakumbura, Pahan Indika& Ranasinghe, Pathmasiri. 2020. In Vitro Antioxidant and Antidiabetic Potentials of Syzygium caryophyllatum L. Alston. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1158564
Modern Language Association (MLA)
Wathsara, Herath Pathiranage Thathmi…[et al.]. In Vitro Antioxidant and Antidiabetic Potentials of Syzygium caryophyllatum L. Alston. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1158564
American Medical Association (AMA)
Wathsara, Herath Pathiranage Thathmi& Weeratunge, Hasitha Dhananjaya& Mubarak, Mohamed Naeem Ahammadu& Godakumbura, Pahan Indika& Ranasinghe, Pathmasiri. In Vitro Antioxidant and Antidiabetic Potentials of Syzygium caryophyllatum L. Alston. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1158564
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158564