Clinical Evaluation of the Safety and Effectiveness of Heptonica: A Ghanaian Hepatorestorative Polyherbal Product
Joint Authors
Appiah, Alfred A.
Ocloo, A.
Mensah, Merlin L. K.
Mensah, Abraham Yeboah
Agyemang, A. O.
Yamile, R. C.
Thomford, K. P.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The incidence of liver diseases is increasing globally, and many patients in developing countries are resorting to the use of herbal products as treatment.
This study was aimed at establishing the safety and effectiveness outcomes for patients with deranged liver panel treated with a Ghanaian finished polyherbal product.
The product Heptonica is prepared by CPMR from three medicinal plants: Bidens pilosa, Citrus aurantifolia, and Trema orientalis.
Fifty (50) participants with clinical and biochemical signs of liver impairment were purposively recruited and treated for a period of 28 days.
Participants received Heptonica at a dose of 30 mL 8 hourly after meals for the treatment period.
Clinical and biochemical evaluation (liver panel test, renal function test, haematology, and urinalysis) of subjects for the safety and effectiveness of the product was undertaken at days 0 (baseline), 14, and 28.
Compared to the baseline values, Heptonica did not have any untoward effect on renal function, haematological parameters, and urine parameters of subjects.
Clinical and liver panel results of the participants also improved compared to the baseline: serum aspartate transaminase (AST) (p < 0.0001), alanine transaminase (ALT) (p < 0.0001), gamma-glutamyltransferase (GGT) (p- 0.0013), total bilirubin (p-0.0136), direct bilirubin (p < 0.0001), total proteins (p-0.0409), and alkaline phosphates (p- 0.0284).
Level of albumin showed no significant difference within the study period.
The outcome of this study indicates Heptonica has hepatorestorative action with no observable toxicity and can be used with confidence as indicated as a liver tonic.
American Psychological Association (APA)
Agyemang, A. O.& Mensah, Merlin L. K.& Yamile, R. C.& Ocloo, A.& Appiah, Alfred A.& Mensah, Abraham Yeboah…[et al.]. 2020. Clinical Evaluation of the Safety and Effectiveness of Heptonica: A Ghanaian Hepatorestorative Polyherbal Product. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1158623
Modern Language Association (MLA)
Agyemang, A. O.…[et al.]. Clinical Evaluation of the Safety and Effectiveness of Heptonica: A Ghanaian Hepatorestorative Polyherbal Product. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1158623
American Medical Association (AMA)
Agyemang, A. O.& Mensah, Merlin L. K.& Yamile, R. C.& Ocloo, A.& Appiah, Alfred A.& Mensah, Abraham Yeboah…[et al.]. Clinical Evaluation of the Safety and Effectiveness of Heptonica: A Ghanaian Hepatorestorative Polyherbal Product. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1158623
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158623