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Emergency Combination of Four Drugs for Bloodstream Infection Caused by Carbapenem-Resistant Enterobacteriaceae in Severe Agranulocytosis Patients with Hematologic Malignancies after Hematopoietic Stem Cell Transplantation
Joint Authors
Li, Xiaofan
Li, Nainong
Hong, Yaqun
Chen, Xianling
Chen, Ping
Source
Emergency Medicine International
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Bloodstream infection (BSI) caused by multidrug-resistant (MDR) bacteria or extensively drug-resistant (XDR) bacteria is a global threat.
However, an effective treatment regimen is still controversial and inadequate due to the rapid deterioration caused by the bacteria.
In immunocompromised and neutropenic patients, MDR-BSI is an emergency, which causes treatment-related mortality.
In this study, four agranulocytosis patients with hematologic malignancies after HSCT receiving treatment for carbapenem-resistant Enterobacteriaceae- (CRE-) BSI were included.
Conventional treatment using two to three combined antibiotics was administered in the first and second patients.
Combination treatment using four drugs, polymyxin B, high-dose tigecycline, fosfomycin, and double-dose carbapenem, was administered in the third and fourth patients.
None of the patients receiving conventional treatment survived.
Both patients receiving combination treatment using four drugs survived.
Therefore, four-drug combination therapy may be needed in CRE-BSI patients who experienced severe agranulocytosis after HSCT.
The efficacy of the four-drug combination treatment for CRE-BSI patients as well as the adverse effects need to be further studied.
American Psychological Association (APA)
Li, Xiaofan& Hong, Yaqun& Chen, Xianling& Chen, Ping& Li, Nainong. 2020. Emergency Combination of Four Drugs for Bloodstream Infection Caused by Carbapenem-Resistant Enterobacteriaceae in Severe Agranulocytosis Patients with Hematologic Malignancies after Hematopoietic Stem Cell Transplantation. Emergency Medicine International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1159184
Modern Language Association (MLA)
Li, Xiaofan…[et al.]. Emergency Combination of Four Drugs for Bloodstream Infection Caused by Carbapenem-Resistant Enterobacteriaceae in Severe Agranulocytosis Patients with Hematologic Malignancies after Hematopoietic Stem Cell Transplantation. Emergency Medicine International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1159184
American Medical Association (AMA)
Li, Xiaofan& Hong, Yaqun& Chen, Xianling& Chen, Ping& Li, Nainong. Emergency Combination of Four Drugs for Bloodstream Infection Caused by Carbapenem-Resistant Enterobacteriaceae in Severe Agranulocytosis Patients with Hematologic Malignancies after Hematopoietic Stem Cell Transplantation. Emergency Medicine International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1159184
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159184