Effects of Vonoprazan Compared with Esomeprazole on the Healing of Artificial Postendoscopic Submucosal Dissection Ulcers: A Prospective, Multicenter, Two-Arm, Randomized Controlled Trial
Joint Authors
Sue, Soichiro
Maeda, Shin
Sasaki, Tomohiko
Kaneko, Hiroaki
Tamura, Toshihide
Kondo, Masaaki
Ishii, Yasuaki
Yamada, Hiroaki
Sato, Takeshi
Irie, Kuniyasu
Ikeda, Ryosuke
Fukuchi, Takehide
Kobayashi, Ryosuke
Makazu, Makomo
Sato, Chiko
Hirasawa, Kingo
Shibata, Wataru
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Vonoprazan affords more clinical benefits than proton pump inhibitors (PPIs) during the healing of gastroduodenal ulcers.
However, it remains controversial whether vonoprazan is more effective than PPIs when used to heal artificial ulcers arising after endoscopic submucosal dissection (ESD).
Aim.
This study investigated the effects of vonoprazan compared with esomeprazole on the healing of post-ESD artificial ulcers.
Methods.
Sixty patients who underwent gastric ESD between May 2015 and May 2017 were randomized to treatment with vonoprazan (V group) or esomeprazole (E group) for 8 weeks.
Upper endoscopy was performed at 4 and 8 weeks after ESD, and drug effects were estimated based on the ulcer healing rates and shrinkage rates.
Results.
Fifty-three patients were analyzed.
The respective 4- and 8-week ulcer healing rates did not differ significantly between V and E groups (8.0 versus 11.5%, P=0.669; 88.9 versus 84.6%, P=0.420).
Similarly, the respective 4- and 8-week ulcer shrinkage rates did not differ significantly between V and E groups (96.8 versus 97.5%, P=0.656; 100 versus 100%, P=0.257).
Conclusion.
The healing of artificial ulcers after ESD did not differ using vonoprazan or esomeprazole.
Both vonoprazan and esomeprazole were effective when used to promote artificial ulcer healing after ESD.
American Psychological Association (APA)
Ishii, Yasuaki& Yamada, Hiroaki& Sato, Takeshi& Sue, Soichiro& Kaneko, Hiroaki& Irie, Kuniyasu…[et al.]. 2018. Effects of Vonoprazan Compared with Esomeprazole on the Healing of Artificial Postendoscopic Submucosal Dissection Ulcers: A Prospective, Multicenter, Two-Arm, Randomized Controlled Trial. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1159253
Modern Language Association (MLA)
Ishii, Yasuaki…[et al.]. Effects of Vonoprazan Compared with Esomeprazole on the Healing of Artificial Postendoscopic Submucosal Dissection Ulcers: A Prospective, Multicenter, Two-Arm, Randomized Controlled Trial. Gastroenterology Research and Practice No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1159253
American Medical Association (AMA)
Ishii, Yasuaki& Yamada, Hiroaki& Sato, Takeshi& Sue, Soichiro& Kaneko, Hiroaki& Irie, Kuniyasu…[et al.]. Effects of Vonoprazan Compared with Esomeprazole on the Healing of Artificial Postendoscopic Submucosal Dissection Ulcers: A Prospective, Multicenter, Two-Arm, Randomized Controlled Trial. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1159253
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159253