Gastric Cancer Maximum Tumour Diameter Reduction Rate at CT Examination as a Radiological Index for Predicting Histopathological Regression after Neoadjuvant Treatment: A Multicentre GIRCG Study
Joint Authors
Volterrani, Luca
Mazzei, Francesco Giuseppe
Roviello, Franco
Mazzei, Maria Antonietta
Marrelli, Daniele
Gentili, Francesco
Baiocchi, Gian Luca
Bagnacci, Giulio
Nigri, Andrea
Pelini, Veronica
Vindigni, Carla
Pittiani, Frida
Morgagni, Paolo
Petrella, Enrico
Mura, Gianni
Verdelli, Beatrice
Bencivenga, Maria
Giacopuzzi, Simone
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aim.
To investigate the role of maximum tumour diameter (D-max) reduction rate at CT examination in predicting histopathological tumour regression grade (TRG according to the Becker grade), after neoadjuvant chemotherapy (NAC), in patients with resectable advanced gastric cancer (AGC).
Materials and Methods.
Eighty-six patients (53 M, mean age 62.1 years) with resectable AGC (≥T3 or N+), treated with NAC and radical surgery, were enrolled from 5 centres of the Italian Research Group for Gastric Cancer (GIRCG).
Staging and restaging CT and histological results were retrospectively reviewed.
CT examinations were contrast enhanced, and the stomach was previously distended.
The D-max was measured using 2D software and compared with Becker TRG.
Statistical data were obtained using “R” software.
Results.
The interobserver agreement was good/very good.
Becker TRG was predicted by CT with a sensitivity and specificity, respectively, of 97.3% and 90.9% for Becker 1 (D-max reduction rate > 65.1%), 76.4% and 80% for Becker 3 (D-max reduction rate < 29.9%), and 70.8% and 83.9% for Becker 2.
Correlation between radiological and histological D-max measurements was strongly confirmed by the correlation index (c.i.= 0.829).
Conclusions.
D-max reduction rate in AGC patients may be helpful as a simple and reproducible radiological index in predicting TRG after NAC.
American Psychological Association (APA)
Mazzei, Maria Antonietta& Bagnacci, Giulio& Gentili, Francesco& Nigri, Andrea& Pelini, Veronica& Vindigni, Carla…[et al.]. 2018. Gastric Cancer Maximum Tumour Diameter Reduction Rate at CT Examination as a Radiological Index for Predicting Histopathological Regression after Neoadjuvant Treatment: A Multicentre GIRCG Study. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1159294
Modern Language Association (MLA)
Mazzei, Maria Antonietta…[et al.]. Gastric Cancer Maximum Tumour Diameter Reduction Rate at CT Examination as a Radiological Index for Predicting Histopathological Regression after Neoadjuvant Treatment: A Multicentre GIRCG Study. Gastroenterology Research and Practice No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1159294
American Medical Association (AMA)
Mazzei, Maria Antonietta& Bagnacci, Giulio& Gentili, Francesco& Nigri, Andrea& Pelini, Veronica& Vindigni, Carla…[et al.]. Gastric Cancer Maximum Tumour Diameter Reduction Rate at CT Examination as a Radiological Index for Predicting Histopathological Regression after Neoadjuvant Treatment: A Multicentre GIRCG Study. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1159294
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159294