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Continuous Use of Combined Hormonal Contraceptive and the Effect on Blood Coagulation Factors in Female Capuchin Monkeys (Sapajus libidinosus)
Joint Authors
Tavares, Maria Clotilde H.
Rodrigues, Rosângela Correa
Belham, Flávia Schechtman
Garcia, Ana
Satler, Corina
Tomaz, Carlos
Source
International Journal of Endocrinology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study aimed at evaluating the availability of the primate Sapajus libidinosus as an animal model for research assessing the physiological effects of the continuous use of combined hormonal contraceptives.
In order to do this, six reproductively active female S.
libidinosus from the Primate Research Center of the University of Brasília were selected to take part in this experiment.
Every 21 days or so, each female received a single dose of combined hormonal contraceptive (algestone acetophenide and 17-enanthate estradiol) in a total of five doses throughout the experiment.
The physiological parameters were accessed by means of 13 blood samples from each female, whereas three were gathered during the baseline and 10 samples were collected during the treatment phase.
The results showed that the contraceptive use provoked changes in hematological coagulation factors such as an increase in the amount of platelets (p=0.039) and a reduction in both prothrombin (p<0.001) and thromboplastin coagulation time (p<0.001).
These results are similar to what has been observed in human patients; thus, it is concluded that S.
libidinosus can be successfully used in studies about the physiological impact of hormonal contraceptives.
American Psychological Association (APA)
Rodrigues, Rosângela Correa& Belham, Flávia Schechtman& Garcia, Ana& Satler, Corina& Tomaz, Carlos& Tavares, Maria Clotilde H.. 2019. Continuous Use of Combined Hormonal Contraceptive and the Effect on Blood Coagulation Factors in Female Capuchin Monkeys (Sapajus libidinosus). International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1159360
Modern Language Association (MLA)
Rodrigues, Rosângela Correa…[et al.]. Continuous Use of Combined Hormonal Contraceptive and the Effect on Blood Coagulation Factors in Female Capuchin Monkeys (Sapajus libidinosus). International Journal of Endocrinology No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1159360
American Medical Association (AMA)
Rodrigues, Rosângela Correa& Belham, Flávia Schechtman& Garcia, Ana& Satler, Corina& Tomaz, Carlos& Tavares, Maria Clotilde H.. Continuous Use of Combined Hormonal Contraceptive and the Effect on Blood Coagulation Factors in Female Capuchin Monkeys (Sapajus libidinosus). International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1159360
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159360