Correlation of Serum 1,5-AG with Uric Acid in Type 2 Diabetes Mellitus with Different Renal Functions

Abstract EN

Aim.

Recent studies found that levels of serum uric acid (SUA) were positively associated with serum 1,5-anhydroglucitol (1,5-AG) in subjects with type 2 diabetes mellitus (T2DM).

In the current study, we investigated the association between 1,5-AG and UA in T2DM patients with different renal functions.

Methods.

A total of 405 T2DM patients, 213 men and 192 women, participated in the study.

Patients’ clinical information was collected, and serum 1,5-AG, SUA, and other clinical characteristics were measured.

Correlation analyses were carried out to analyze their correlation with serum 1,5-AG and SUA.

Results.

The male group showed higher levels of SUA than the female group (282.1 ± 91.2 and 244.7 ± 71.89 μmol/L, respectively, P<0.01).

Pearson’s correlation coefficients determine that SUA was positively associated with 1,5-AG in both men (r=0.213, P<0.05) and women (r=0.223, P<0.05), and such relationship can be influenced by the renal function.

The positive association still existed with moderate impaired renal function.

Moreover, 1,5-AG had a negative association with haemoglobin A1c (HbA1c) in T2DM subjects with eGFR ≥ 30 mL/min/1.73 m2 (P<0.01).

Conclusion.

The positive association between SUA and 1,5-AG still exists in T2DM with moderate renal failure.

1,5-AG can still reflect the glucose levels in patients with CKD stages 1-3.